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Pharmacy Friday Pearls

Every Friday, get a concise clinical pearl delivered straight to your inbox. Evidence-based insights you can apply at the bedside — written by pharmacists, for pharmacists.

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Concise. Evidence-Based. Practice-Changing.

Each Pharmacy Friday Pearl is a focused, evidence-based summary of a clinically relevant topic. Written by practicing pharmacists with expertise in emergency medicine, critical care, and acute care, every pearl distills complex literature into actionable bedside knowledge.

Pearls take just 3–5 minutes to read and are designed to fit into your morning routine — whether you are prepping for rounds, catching up between shifts, or reviewing on your commute.

Every pearl includes key takeaways and clinical applications so you can immediately translate evidence into practice. No paywalls, no fluff — just the information that matters.

What Makes a Great Pharmacy Pearl

Single focused topic
Evidence from landmark or recent trials
Clear clinical application
Written by specialist pharmacists
Peer-reviewed for accuracy
3–5 minute read time
Pharmacy Pearls

Browse Our Clinical Pearl Library

Clinical Pearls live at /pearls/{topic}/. Older top-level Pearl links redirect here.

Emergency Medicine

Sodium Bicarbonate in DKA

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing sodium bicarbonate use in diabetic ketoacidosis, adult evidence, harms, and rare dosing scenarios.

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Clinical Pearls

Systemic Thrombolysis in PE

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing systemic thrombolysis for pulmonary embolism and practical pharmacist decision points.

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Emergency Medicine

Refractory Anaphylaxis

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing refractory anaphylaxis management, epinephrine infusion escalation, glucagon, second-line vasopressors, and rescue therapy.

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Cardiology

P2Y12 Loading in NSTE-ACS

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing P2Y12 loading decisions in NSTE-ACS, cath-lab handoffs, and duplicate-load prevention.

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Emergency Medicine

Ketamine RSI

By Jimmy Pruitt; Richard LaCoursiere · May 16, 2026

A Pharmacy Friday Pearl comparing ketamine and etomidate for rapid sequence intubation in emergency and critically ill patients.

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Toxicology

Digoxin Poisoning

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing digoxin poisoning recognition, digoxin immune Fab dosing, administration, and monitoring.

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Hematology

Hemophilia Factor Products

By Folashade O. Alabi; Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing factor products, dosing, bypassing agents, and evidence for hemophilia-related bleeding management.

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Emergency Medicine

Phenylephrine for Priapism

By Folashade O. Alabi; Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing intracavernosal phenylephrine dosing, monitoring, and evidence for ischemic priapism.

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Emergency Medicine

Buprenorphine MAT

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing buprenorphine medication-assisted therapy considerations in the emergency department.

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Toxicology

CCB and BB Toxicity

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing initial management options for calcium channel blocker and beta blocker toxicity.

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Cardiology

Esmolol in Refractory VF

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing esmolol as an adjunctive strategy in refractory ventricular fibrillation cardiac arrest.

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Emergency Medicine

Gout Management in the ED

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing NSAIDs, corticosteroids, and colchicine for acute gout in the emergency department.

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Emergency Medicine

Hypertensive Emergency

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing intravenous antihypertensive selection for hypertensive emergency presentations.

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Emergency Medicine

Opioid Alternatives

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing non-opioid medication options for mild-to-moderate pain in the emergency department.

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Toxicology

Physostigmine

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing physostigmine dosing, cautions, and evidence in anticholinergic toxidrome.

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Neurology

Ketamine for RSE

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing ketamine as an adjunctive option for refractory status epilepticus.

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Emergency Medicine

Paralytics for RSI

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing neuromuscular blocking agent selection for rapid sequence intubation.

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Critical Care

Post-Intubation Sedation

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing immediate post-intubation analgesia and sedation priorities.

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Emergency Medicine

Hereditary Angioedema

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing hereditary angioedema recognition and acute treatment options.

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Cardiology

tPA in Cardiac Arrest

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing thrombolytic therapy considerations for suspected thrombosis in cardiac arrest.

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Emergency Medicine

Droperidol for Agitation

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing droperidol efficacy, dosing, and safety for acute agitation.

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Infectious Disease

Nitrofurantoin for UTI

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing nitrofurantoin use for cystitis and urinary tract infections.

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Emergency Medicine

Anaphylaxis Pharmacotherapy

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing epinephrine, anaphylaxis treatment, and biphasic reaction considerations.

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Emergency Medicine

Non-Occupational PEP

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing non-healthcare post-exposure prophylaxis considerations.

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Emergency Medicine

Antiemetics and QTc

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing QTc prolongation considerations when selecting antiemetics.

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Toxicology

Crotalid Envenomation

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing antivenom and supportive management for crotalid envenomation.

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Cardiology

BB vs CCB for Afib

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing beta blockers versus calcium channel blockers for atrial fibrillation rate control.

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Critical Care

Thyroid Storm

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing emergency pharmacotherapy for thyroid storm.

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Emergency Medicine

ACEi Angioedema

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing bradykinin-mediated ACE inhibitor-induced angioedema.

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Critical Care

Tumor Lysis Syndrome

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing tumor lysis syndrome prevention and treatment.

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Emergency Medicine

Cannabinoid Hyperemesis

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing pharmacotherapy for cannabinoid hyperemesis syndrome.

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Emergency Medicine

Antiemetics for N/V

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing antiemetic selection for nausea and vomiting.

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Emergency Medicine

Steroids in Asthma/COPD

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing corticosteroid therapy in asthma and COPD exacerbations.

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Emergency Medicine

Etomidate RSI Septic Shock

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing etomidate for rapid sequence intubation in septic shock patients.

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Emergency Medicine

TXA for Minor Bleeding

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing tranexamic acid for minor bleeding presentations.

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Emergency Medicine

Ultrasound-Guided Nerve Blocks

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing ultrasound-guided peripheral nerve blocks and pharmacotherapy considerations.

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Emergency Medicine

Lorazepam vs Midazolam

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl comparing lorazepam and midazolam for acute agitation.

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Emergency Medicine

RSI Induction Medications

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing induction medication options for rapid sequence intubation.

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Critical Care

3% HTS for Hyponatremia

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing 3% sodium chloride for severe symptomatic hyponatremia.

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Cardiology

Procainamide for WCT

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing procainamide for hemodynamically stable wide complex tachycardia.

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Neurology

HTS vs Mannitol for ICP

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl comparing hypertonic saline and mannitol for intracranial pressure reduction.

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Neurology

Alteplase for AIS

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing alteplase evidence and pharmacotherapy considerations for acute ischemic stroke.

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Neurology

Seizure Prophylaxis in TBI

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing antiseizure prophylaxis choices and timing in traumatic brain injury.

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Neurology

Fosphenytoin vs Keppra

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl comparing fosphenytoin and levetiracetam as second-line therapy for status epilepticus.

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Emergency Medicine

Parenteral Benzos and Olanzapine

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing safety considerations for parenteral benzodiazepine and olanzapine coadministration.

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Emergency Medicine

Hypocalcemia in Trauma

By Jimmy Pruitt · May 16, 2026

A Pharmacy Friday Pearl reviewing hypocalcemia, calcium replacement, and pharmacist considerations during trauma resuscitation.

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Infectious Disease

PROPHY-VAP Trial

By Jimmy Pruitt · January 22, 2024

A Pharmacy Friday Pearl reviewing PROPHY-VAP Trial.

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