Alteplase for Acute Ischemic Stroke
Introduction Alteplase (rt-PA) has been used for acute ischemic stroke since its approval by the FDA in 1996 after publication of promising results of…
Category: Pharmacy Friday Pearls
Hypertonic Saline Versus Mannitol for ICP Reduction
Introduction Elevated intracranial pressure (ICP) is caused by excess volume in the cerebral spaces, which causes a reduction in the cerebral perfusion pressure and…
Fosphenytoin vs Keppra for Status Epilepticus
Introduction Status epilepticus is a neurological emergency that required urgent assessment and treatment with pharmacologic agents Lorazepam and diazepam are short-acting drugs that can produce…
Management of Hypertensive Emergency
Introduction Hypertensive emergency is characterized by systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 120 mmHg with evidence of target…
Fibrinolytics for STEMI
Introduction Percutaneous coronary intervention (PCI) is the preferred reperfusion strategy during a cardiac arrest; thrombolytic therapy is an option without PCI capability, followed by transfer…
Procainamide for Wide Complex Tachycardia
Introduction Ventricular tachycardia (VT) is an uncommon but dangerous medical condition, with an extremely variable clinical presentation. Intravenous procainamide is guideline recommended and is the…
Push Dose Vasopressors
Patient Case The team gets a call that there is a 75 year old male that triggered a sepsis alert in route with EMS…
Sodium Bicarbonate in Cardiac Arrest
Introduction Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality and a substantial issue of public health concern worldwide. Sodium bicarbonate (SB) administration has…