PROPHY-VAP Trial
The PROPHY-VAP trial showed that a single dose of ceftriaxone can significantly reduce early-onset VAP in mechanically ventilated brain-injured patien…
Author: Jimmy
Piperacillin-tazobactam plus Vancomycin and Acute Kidney Injury by Caroline Rosario
Introduction Pharmacology Vancomycin Piperacillin-tazobactam4 Dose Depends on infection and PK/PD target General dosing for systemic infections: IV 15-20 mg/kg IV Q8-12H for systemic infections…
Seizure Prophylaxis in Traumatic Brain Injury by Jordan Spurling
Introduction Pharmacology Phenytoin Valproic Acid Levetiracetam Lacosamide Dose Loading dose: 17 to 20 mg/kg IV (max dose 2 g) Maintenance dose: 100 mg…
Penicillin Allergy Cross Reactivity
Introduction Pharmacology Group 1 Group 2 Group 3 Group 4 PenicillinCefoxitinCefuroxime AmoxicillinAmpicillinCefaclorCephalexinCefadroxil CeftriaxoneCefotaximeCefuroximeCefepimeCefpodoxime Ceftaroline AztreonamCeftolazane Ceftazidime Overview of Evidence Author Design Intervention & Comparison Outcome…
Corticosteroids in Sepsis by Marissa Marks, PharmD
Introduction Pharmacology Hydrocortisone Methylprednisolone Fludrocortisone Dose IV: 50 mg Q6H or 100 mg Q8H x 5-7 days IV (succinate): 40 to 125 mg/day (maximum…
Etomidate for RSI: Seizure Considerations
Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal…
Ketamine for Treatment of Acute Agitation
Introduction Ketamine is a sedative used for patients with extreme/refractory undifferentiated agitation Indications for utilizing ketamine for emergent sedation of agitated patients include Patient poses…
PPIs for the Management of Upper GI Bleed
Introduction Upper GI bleed (UGIB) is a common reason for ED visits with a major cause of morbidity, mortality and medical care costs. Peptic ulcer…
Single-Dose Aminoglycosides for UTIs
Ratione molestias magnam quisquam non non dolores omnis incidunt et accusamus eum rerum quam ipsum impedit a ea excepturi et ut reprehenderit tempore …
Concomitant Parenteral Benzodiazepines and Olanzapine
Introduction Intramuscular olanzapine and parenteral benzodiazepines are commonly used agents in the ED for acute agitation. An FDA warning states that potentially fatal respiratory depression…