Internal Medicine 101
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Pneumonia
Community-Acquired Pneumonia9 Topics|3 Quizzes-
Pre-Quiz: Community-Acquired Pneumonia
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Background
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Epidemiology, Risk Factors, and Etiology
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Pathophysiology and Clinical Manifestations
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Diagnostic Tests
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Treatment and Management
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Literature Review: Community-Acquired Pneumonia
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Post-Quiz: Community-Acquired Pneumonia
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Post-Lesson Feedback Survey for Internal Medicine 101: Community-Acquired Pneumonia
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Pre-Quiz: Community-Acquired Pneumonia
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Venous Thromboembolic DiseaseAcute Management of Pulmonary Embolism12 Topics|2 Quizzes
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Pre-Quiz: Acute Management of Pulmonary Embolism
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Introduction
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Epidemiology and Pathophysiology
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Clinical Presentation
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Diagnosis and Risk Stratification
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General Approaches
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Anticoagulation in Acute Pulmonary Embolism with Literature Review
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Thrombolytic Therapy in Acute Pulmonary Embolism with Literature Review
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Ancillary Therapies in the Management of Pulmonary Embolism
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Summary and References
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Post-Quiz: Acute Management of Pulmonary Embolism
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Post-Lesson Feedback Survey for Internal Medicine 101: PE
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Pre-Quiz: Acute Management of Pulmonary Embolism
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Acute Management of DVT10 Topics|2 Quizzes
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Diabetes and HyperglycemiaHyperglycemia in Hospitalized Patients11 Topics|2 Quizzes
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Pre-Quiz: Hyperglycemia in Hospitalized Patients
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Introduction
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Clinical Presentation
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Pathophysiology
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Diagnostic Approach
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Pharmacotherapy
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Management of Hypoglycemia in Hospitalized Patients
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Literature Review: Key Guidelines and Studies for Hyperglycemia in Hospitalized Patients
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Summary and References
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Post-Quiz: Hyperglycemia in Hospitalized Patients IM 101
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Post-Lesson Feedback Survey for Internal Medicine 101: Hyperglycemia
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Pre-Quiz: Hyperglycemia in Hospitalized Patients
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Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome13 Topics|3 Quizzes
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Pre-Quiz: Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome
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Introduction
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Clinical Presentation
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Pathophysiology
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Risk Factors and Precipitating Triggers
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Diagnostic Approach
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Fluid Resuscitation
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Insulin Therapy
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Hypoglycemia Management
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Literature Review: Hyperglycemic Crisis
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References
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Post-Quiz: Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome IM 101
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Post-Lesson Feedback Survey for Internal Medicine 101: DKA & HHS
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Pre-Quiz: Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome
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Pulmonary ExacerbationsChronic Obstructive Pulmonary Disease Exacerbation10 Topics|3 Quizzes
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Pre-Quiz: Chronic Obstructive Pulmonary Disease Exacerbation
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Introduction to COPD Exacerbation
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Pathophysiology of COPD Exacerbation
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Clinical Manifestations
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Diagnostic Criteria and Assessment
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Management
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Literature Review: Key Guidelines and Studies
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Summary and References
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Post-Quiz: Chronic Obstructive Pulmonary Disease Exacerbation
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Post-Lesson Feedback Survey for Internal Medicine 101: COPD
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Pre-Quiz: Chronic Obstructive Pulmonary Disease Exacerbation
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Asthma Exacerbation15 Topics|3 Quizzes
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Pre-Quiz: Asthma Exacerbation
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Introduction to Asthma Exacerbation
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Pathophysiology
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Risk Factors and Precipitating Triggers
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Clinical Manifestations
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Diagnostic Criteria and Assessment
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Non-Pharmacological Management
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Pharmacological Management
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Complications and Emergency Management
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Monitoring and Follow-up
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Discharge Planning and Patient Education
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Literature Review: Asthma Exacerbation
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Summary and References
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Post-Quiz: Asthma Exacerbation
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Post-Lesson Feedback Survey for Internal Medicine 101: Asthma Exacerbation
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Pre-Quiz: Asthma Exacerbation
Participants 396
Summary and References
The acute management of deep vein thrombosis (DVT) involves a multifaceted approach that includes identification of risk factors, accurate diagnosis, risk stratification, and pharmacological treatment. The course has provided a deep dive into these various aspects, discussing the epidemiology and pathophysiology of DVT, diagnostic modalities, anticoagulant options, interventional therapies, and the approach to special populations and complications.
Risk stratification through clinical prediction rules like the Wells score, as well as the interpretation of D-dimer test results and Doppler ultrasonography, play crucial roles in diagnosis. Anticoagulation remains the cornerstone of treatment, with several options including heparin, low molecular weight heparin (LMWH), fondaparinux, and direct oral anticoagulants (DOACs) like rivaroxaban, apixaban, and edoxaban. Transitioning between these agents and determining the appropriate duration of therapy is equally important.
References
- Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol. 2008;28(3):370-372.
- Kearon C. Natural history of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I22-I30.
- Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011;123(16):1788-1830.
- Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019;54(3):1901647.
- Roberts LN, Patel RK, Arya R. Venous thromboembolism and ethnicity. Br J Haematol. 2009;146(4):369-383.
- Streiff MB, Lau BD. Thromboprophylaxis in medically ill patients. Discov Med. 2014;18(100):173-180.
- White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I4-I8.
- Linkins LA, Dans AL, Moores LK, et al. Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e495S-e530S.
- Ortel TL, Neumann I, Ageno W, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2020;4(19):4693-4738.
- Stevens SM, Woller SC, Kreuziger LB, et al. Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021;160(6):e545-e601.
- Schulman S, Kakkar AK, Goldhaber SZ, et al; RE-COVER II Trial Investigators. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation. 2014;129(7):764-772.
- Bauersachs R, Berkowitz SD, Brenner B, et al; EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363(26):2499-2510.
- Agnelli G, Buller HR, Cohen A, et al; AMPLIFY Investigators. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med. 2013;369(9):799-808.
- Hokusai-VTE Investigators, Büller HR, Décousus H, et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369(15):1406-1415.
- Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315-352.
- Hull RD, Pineo GF, Brant RF, et al; LITE Trial Investigators. Home therapy of venous thrombosis with long-term LMWH versus usual care: patient satisfaction and post-thrombotic syndrome. Thromb Haemost. 2009;102(1):41-48.
- Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349(2):146-153.
- Agnelli G, Becattini C, Meyer G, et al; AMPLIFY-EXT Investigators. Apixaban for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2013;368(8):699-708.
- Weitz JI, Lensing AWA, Prins MH, et al; EINSTEIN CHOICE Investigators. Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017;376(13):1211-1222.
- Douketis JD, Foster GA, Crowther MA, Prins MH, Ginsberg JS. Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med. 2000;160(22):3431-3436.
- Linkins LA, Choi PT, Douketis JD. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis. Ann Intern Med. 2003;139(11):893-900.