PGY1 MICU 211
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Stress Ulcer Prophylaxis12 Topics|2 Quizzes
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DVT Prophylaxis10 Topics|2 Quizzes
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Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome11 Topics|3 Quizzes
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Introduction to Shock and Hemodynamics5 Topics|2 Quizzes
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Sepsis11 Topics|2 Quizzes
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Post-Intubation Sedation8 Topics|2 Quizzes
Participants 396
Summary and References
Sepsis management demands acute clinical awareness and swift intervention. Key learning points encompass recognizing the hallmark signs of sepsis—fever, tachycardia, tachypnea, and hypotension—along with understanding risk factors that heighten susceptibility. Early intervention through aggressive fluid resuscitation and appropriate broad-spectrum antibiotics is paramount. Emphasize the significance of source control in localized infections and the principles of antibiotic stewardship for tailored treatment. In fluid-refractory cases, grasp the importance of continuous hemodynamic monitoring and the potential need for vasopressor support. Collaborate closely with critical care specialists if necessary. By mastering these takeaways, clinical pharmacists can confidently navigate sepsis cases, optimizing patient care and contributing to improved outcomes.
References and Bibliography
- Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med. 2017;45(3):486-552. doi:10.1097/CCM.0000000000002255
- Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181-1247. doi:10.1007/s00134-021-06506-y
- Clancy CJ, Bassetti M, Bilker WB, et al. Official Clinical Practice Guideline for the Diagnosis and Management of Candidiasis: 2022 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2022;ciaa1769. doi:10.1093/cid/ciaa1769
- Landry DW, Patel SM, Cohen MJ, Reisman WM. Sepsis: Diagnosis and Management. JAMA. 2022;328(13):1300-1311. doi:10.1001/jama.2022.15743
- Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):762-774. doi:10.1001/jama.2016.0288
- Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-1377. doi:10.1056/NEJMoa010307
- Annane D, Sébille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288(7):862-871. doi:10.1001/jama.288.7.862
- Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med. 2008;358(9):877-887. doi:10.1056/NEJMoa067373
- Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358(2):111-124. doi:10.1056/NEJMoa071366
- Yealy DM, Kellum JA, Huang DT, et al; ProCESS Investigators. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370(18):1683-1693. doi:10.1056/NEJMoa1401602