Summary

DVT prophylaxis is recommended for most critically ill patients, with preference for pharmacologic agents like LMWH or LDUH over mechanical prophylaxis. LMWH and LDUH have shown similar efficacy and safety. Mechanical methods like intermittent pneumatic compression are reasonable alternatives in high bleeding risk patients. Trauma and surgical patients should receive prophylaxis based on their VTE and bleeding risks. Ongoing assessment for bleeding risk is needed, and prophylaxis adjusted accordingly. The goal is to provide adequate thromboprophylaxis while minimizing bleeding complications.