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Pharmacy & Acute Care University
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Internal Medicine 101

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  1. Pneumonia 

    Community-Acquired Pneumonia
    9 Topics
    |
    3 Quizzes
  2. Venous Thromboembolic Disease
    Acute Management of Pulmonary Embolism
    12 Topics
    |
    2 Quizzes
  3. Acute Management of DVT
    10 Topics
    |
    2 Quizzes
  4. Diabetes and Hyperglycemia
    Hyperglycemia in Hospitalized Patients
    11 Topics
    |
    2 Quizzes
  5. Hyperglycemic Crisis: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome
    13 Topics
    |
    3 Quizzes
  6. Pulmonary Exacerbations
    Chronic Obstructive Pulmonary Disease Exacerbation
    10 Topics
    |
    3 Quizzes
  7. Asthma Exacerbation
    15 Topics
    |
    3 Quizzes

Quizzes

Participants 396

  • Allison Clemens
  • April
  • ababaabhay
  • achoi2392
  • adhoward1
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Internal Medicine 101 Asthma Exacerbation Complications and Emergency Management
Lesson 7, Topic 9
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Complications and Emergency Management

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Asthma exacerbations can lead to severe complications that require immediate intervention. Timely recognition and management of these complications are crucial to prevent further deterioration and ensure optimal patient outcomes. This section will explore the potential complications of asthma exacerbations and outline evidence-based emergency management strategies.

Severe Exacerbations

Definition and Recognition

  • Respiratory Distress: Marked increase in effort to breathe, accessory muscle use
  • Decreased Breath Sounds: Indicates significant airflow obstruction
  • Altered Mental Status: Confusion, agitation, or decreased responsiveness

Management

  • Oxygen Therapy: Maintain SpO2 ≥ 90%
  • Bronchodilators: Frequent or continuous nebulized SABAs
  • Corticosteroids: Systemic steroids as early as possible
  • Consider Intubation: If progressive worsening despite treatment

Respiratory Failure

Definition and Recognition

  • Type I (Hypoxemic) Failure: PaO2 < 60 mm Hg with normal or low PaCO2
  • Type II (Hypercapnic) Failure: PaCO2 > 45 mm Hg with accompanying hypoxemia

Management

  • Non-Invasive Ventilation (NIV): CPAP or BiPAP
  • Mechanical Ventilation: If NIV is not sufficient or contraindicated
  • Ventilation Strategies: Lung-protective strategies; avoid barotrauma

Associated Comorbidities

  • Pneumothorax: Monitor for sudden worsening; may require chest tube
  • Pneumonia: Consider antibiotics if signs of infection
  • Heart Failure: Monitor fluid status; consider diuretics

Emergency Pharmacological Interventions

  • Magnesium Sulfate: Consider in severe exacerbations
  • Epinephrine/Terbutaline: If unresponsive to other treatments
  • Ketamine: Consider for bronchodilation and sedation if intubation required

Special Considerations

  • Pregnancy: Monitor fetal status; avoid delays in treatment
  • Pediatric Patients: Tailor interventions to age and size
  • Chronic Comorbidities: Consider impacts of COPD, heart disease, etc.

Summary

Complications of asthma exacerbations can escalate rapidly, leading to life-threatening situations. Comprehensive management includes the recognition of severe exacerbations and respiratory failure, the application of emergency pharmacological interventions, and the consideration of specific patient factors such as pregnancy or chronic comorbidities.

Early intervention, guided by evidence-based protocols and a multidisciplinary approach, is essential to prevent further complications and provide the best chance for recovery.