Literature Review Quiz: Hyperglycemic Crisis

Which of the following was a primary objective of the study “Prospective Randomized Trial of Insulin Glargine in Acute Management of Diabetic Ketoacidosis in the Emergency Department: A Pilot Study”?

A) To determine if co-administration of subcutaneous insulin glargine with intravenous insulin decreases time to resolution of ketoacidosis compared to standard management.
B) To compare different intravenous insulin infusion rates for treating diabetic ketoacidosis.
C) To evaluate the safety of using only subcutaneous insulin glargine for treating diabetic ketoacidosis.
D) To develop a new protocol for fluid resuscitation in patients with diabetic ketoacidosis.

In the study “Prospective Randomized Trial of Insulin Glargine in Acute Management of Diabetic Ketoacidosis in the Emergency Department: A Pilot Study”, how were patients in the experimental group managed after closure of the anion gap?

A) Intravenous insulin was discontinued and long-acting subcutaneous insulin was restarted.
B) The insulin glargine dose was increased and intravenous insulin was continued.
C) Intravenous insulin was continued and no additional subcutaneous insulin was given.
D) Both intravenous and subcutaneous insulin were discontinued.

What was the primary outcome measured in the study “Prospective Randomized Trial of Insulin Glargine in Acute Management of Diabetic Ketoacidosis in the Emergency Department: A Pilot Study”?

A) Time to normalization of blood glucose
B) Incidence of hypoglycemic events
C) Time to closure of anion gap
D) Length of hospital stay

Based on the results of the study “Prospective Randomized Trial of Insulin Glargine in Acute Management of Diabetic Ketoacidosis in the Emergency Department: A Pilot Study”, which of the following statements is most accurate?

A) The experimental treatment significantly decreased time to closure of anion gap compared to standard treatment.
B) The experimental treatment significantly increased the risk of hypoglycemic events.
C) The experimental treatment significantly shortened hospital length of stay.
D) There were no statistically significant differences in outcomes between the two treatment groups.

What was one of the main conclusions of the systematic review on the use of bicarbonate therapy for diabetic ketoacidosis (DKA)?

A) Bicarbonate therapy significantly improves acidosis resolution time compared to standard therapy.
B) Bicarbonate therapy reduces the risk of neurological complications like cerebral edema in DKA.
C) The evidence does not support routine use of bicarbonate therapy for DKA due to lack of benefits and possible harms.
D) Bicarbonate therapy should be used in all DKA patients with pH < 6.90.

Which of the following was identified as a possible harm associated with bicarbonate therapy for DKA in the review?

A) Increased insulin resistance
B) Prolonged hyperglycemia
C) Increased risk of cerebral edema in children
D) Improved tissue oxygenation

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