Tranexamic Acid in Trauma
By PACU Editorial
When to give TXA, optimal dosing windows, and the evidence from CRASH-2 and CRASH-3 for trauma-related hemorrhage.
Read Pearl
Free Weekly Series
Pharmacy Friday Pearls
Every Friday, get a concise clinical pearl delivered straight to your inbox. Evidence-based insights you can apply at the bedside — written by pharmacists, for pharmacists.
50+
Clinical Pearls Published
Every
Friday Delivery
Free
No Subscription Required
Quick Clinical Insights
Concise. Evidence-Based. Practice-Changing.
Each Pharmacy Friday Pearl is a focused, evidence-based summary of a clinically relevant topic. Written by practicing pharmacists with expertise in emergency medicine, critical care, and acute care, every pearl distills complex literature into actionable bedside knowledge.
Pearls take just 3–5 minutes to read and are designed to fit into your morning routine — whether you are prepping for rounds, catching up between shifts, or reviewing on your commute.
Every pearl includes key takeaways and clinical applications so you can immediately translate evidence into practice. No paywalls, no fluff — just the information that matters.
What Makes a Great Pharmacy Pearl
Single focused topic
Evidence from landmark or recent trials
Clear clinical application
Written by specialist pharmacists
Peer-reviewed for accuracy
3–5 minute read time
Recent Pearls
Browse Our Clinical Pearl Library
Ketamine for Acute Agitation
By PACU Editorial
IM ketamine dosing, onset considerations, and safety profile for managing severe agitation in the emergency department.
Read PearlCorticosteroids in Sepsis
By PACU Editorial
Reviewing ADRENAL, APROCCHSS, and current guideline recommendations for hydrocortisone in septic shock.
Read PearlProcainamide for Wide Complex Tachycardia
By PACU Editorial
Dosing strategies, infusion rates, and when procainamide should be first-line over amiodarone in stable WCT.
Read PearlHigh-Dose Nitroglycerin for SCAPE
By PACU Editorial
Bolus-dose nitroglycerin protocols for sympathetic crashing acute pulmonary edema and evidence supporting early aggressive vasodilation.
Read PearlFosphenytoin vs Keppra for Status Epilepticus
By PACU Editorial
Head-to-head comparison from the ESETT trial and practical considerations for second-line seizure management.
Read PearlPPIs for Upper GI Bleed
By PACU Editorial
Intermittent vs continuous PPI infusions, optimal timing relative to endoscopy, and evidence-based dosing strategies.
Read PearlAlteplase for Acute Ischemic Stroke
By PACU Editorial
Dosing, time windows, inclusion and exclusion criteria, and blood pressure management during thrombolytic administration.
Read PearlPenicillin Allergy Cross-Reactivity
By PACU Editorial
True cross-reactivity rates between penicillins, cephalosporins, and carbapenems — and why most reported allergies are not real.
Read PearlHypertonic Saline vs Mannitol for ICP Reduction
By PACU Editorial
Comparing osmotic agents for elevated intracranial pressure: concentrations, dosing, onset, and the latest comparative evidence.
Read PearlStatins for STEMI in the ED
By PACU Editorial
Early high-intensity statin therapy in STEMI: timing, agent selection, and the pleiotropic effects beyond lipid lowering.
Read PearlNorepinephrine vs Epinephrine in Post-Cardiac Arrest Shock
By PACU Editorial
Vasopressor selection after ROSC: hemodynamic considerations, metabolic effects, and current guideline recommendations.
Read PearlACURASYS: Neuromuscular Blockade in ARDS
By PACU Editorial
Evidence for cisatracurium in early severe ARDS, updated by the ROSE trial, and practical application at the bedside.
Read PearlAnticoagulant Reversal in Traumatic ICH
By PACU Editorial
Is reversal necessary in neurologically intact patients? Evidence-based review of reversal agents and risk-benefit considerations.
Read PearlConcomitant Parenteral Benzodiazepines & Olanzapine
By PACU Editorial
Examining the FDA black-box warning, real-world risk data, and clinical scenarios where the combination may still be used safely.
Read PearlPharmacist-Driven Deprescribing for UTI/STI
By PACU Editorial
Pharmacist-led protocol for deprescribing antibiotics in negative urine and STI cultures to reduce unnecessary exposure.
Read PearlEtomidate for RSI: Seizure Considerations
By PACU Editorial
Does etomidate lower seizure threshold? Examining the evidence and when to choose an alternative induction agent.
Read PearlPip-Tazo + Vancomycin and Acute Kidney Injury
By PACU Editorial
Quantifying nephrotoxicity risk with the combination, monitoring strategies, and when to switch to alternative agents.
Read PearlPROPHY-VAP Trial
By PACU Editorial
Prophylactic ceftriaxone vs. placebo in comatose patients and the impact on ventilator-associated pneumonia rates.
Read PearlSeizure Prophylaxis in Traumatic Brain Injury
By PACU Editorial
Duration of prophylaxis, levetiracetam vs phenytoin, and current guideline recommendations for post-traumatic seizure prevention.
Read PearlSingle-Dose Aminoglycosides for UTIs
By PACU Editorial
Efficacy of single-dose gentamicin or tobramycin for uncomplicated UTIs compared to multi-day regimens.
Read PearlTenecteplase vs Alteplase for Acute Ischemic Stroke (AcT)
By PACU Editorial
The AcT trial results, dosing comparison, and practical considerations for transitioning to tenecteplase in stroke.
Read PearlGet Pharmacy Pearls in Your Inbox Every Friday
Join 2,000+ pharmacists who start their Fridays with a clinical pearl.
Free forever. Unsubscribe anytime. No spam, ever.
Go Further
Take Your Education Further
Pharmacy Pearls are just the beginning. Explore our full suite of pharmacy education products.
PACULit
Get 15 curated literature summaries per month plus CE credits in your specialty track. Save 5+ hours of reading time every week.
Learn MorePACU Core
Full access to 136+ expert-led courses, reference materials, study tools, and community forums. The complete CE solution.
View PlansBecome a Contributor
Share your clinical expertise with the pharmacy community. Write your own Pharmacy Pearls and build your professional profile.
Apply NowNever Miss a Friday Pearl
Subscribe for free and get concise, evidence-based clinical insights delivered to your inbox every week.
Subscribe Free 50+ Pearls Published
Every Friday
Always Free