Prophylaxis

• Patients may require antibiotics during or shortly after completion of CDI therapy
• Concern regarding recurrence with ending CDI treatment but continuing other antibiotics
• No prospective, RCTs

• Guideline Recommendations:
  • Administer lower doses of standard of care antibiotics
    • Vancomycin 125mg daily
    • Fidaxomicin 200mg daily
  • IF prevention agent is warranted while systemic antibiotics are administered

Prophylaxis Candidates

• Considerations for Secondary Prophylaxis:
  • Length of time from completion of CDI treatment
  • Patient characteristics:
    • Number of previous CDI episodes
    • Severity of presentation
    • Patient frailty