- Patients may require antibiotics during or shortly after completion of CDI therapy
- Concern regarding recurrence with ending CDI treatment but continuing other antibiotics
- No prospective, RCTs
- Guideline Recommendations:
- Administer lower doses of standard of care antibiotics
- IF prevention agent is warranted while systemic antibiotics are administered
Prophylaxis Candidates
- Considerations for Secondary Prophylaxis:
- Length of time from completion of CDI treatment
- Patient characteristics:
- Number of previous CDI episodes