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  1. Intensive Care Unit (ICU) or Stroke Unit admission
  2. Strict blood pressure monitoring 
    • Goal BP <180/105 mmHg 
      • Must be maintained during infusion and 24 hours after administration 
    • BP monitoring is as followed 
      • Every 15 minutes for 2 hours (from start of fibrinolytic therapy) then
      • Every 30 minutes for 6 hours then 
      • Every hour for 16 hours 
  3. Obtain follow up CT or MRI 24 hours after fibrinolytic treatment prior to initiating anticoagulation/antiplatelet agents