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2025 PACUPrep BCCCP Preparatory Course Potassium Disorders Supportive Care Measures and Monitoring in the Management of Potassium Disorders

Lesson 90, Topic 4

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Supportive Care Measures and Monitoring in the Management of Potassium Disorders

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Supportive Care in Potassium Disorders

Supportive Care Measures and Monitoring in the Management of Potassium Disorders

Learning Objective

Recommend supportive care and monitoring strategies to minimize treatment-related complications and optimize outcomes in patients with dyskalemias.

1. Cardiac and Hemodynamic Monitoring

Continuous electrical and hemodynamic monitoring is essential during severe potassium disturbances and rapid IV therapies to detect arrhythmogenic triggers early.

Key Monitoring Parameters

Summary of Essential Monitoring for Dyskalemia
Parameter	Indication / Threshold	Rationale & Key Considerations
Continuous Telemetry	K+ <2.5 or >6.0 mEq/L; IV rate ≥10 mEq/hr	Detects arrhythmias, QRS/QTc changes. Use Lead II for T-waves, V5 for ST changes.
12-Lead ECG	At diagnosis & to confirm any telemetry changes	Provides definitive diagnosis of cardiotoxicity and rules out artifact (e.g., motion, tremor).
Alarm Thresholds	QRS >120 ms; QTc >500 ms; T-wave >5 mm	Triggers for immediate clinical re-evaluation and potential intervention.
Hemodynamics	Hourly MAP & Urine Output	Tracks end-organ perfusion. Dynamic indices (PPV/SVV) useful in ventilated patients.

Clinical Pearls

Always verify alarming telemetry with a 12-lead ECG to avoid false positives from artifact and ensure appropriate treatment.
Maintain serum potassium between 4.0–4.5 mEq/L and magnesium greater than 2.0 mg/dL to synergistically reduce arrhythmia risk, especially in cardiac patients.

2. Prevention and Management of Iatrogenic Complications

Proactive measures and monitoring protocols are critical to prevent harms such as extravasation, rebound dyskalemia, hypoglycemia, and gastrointestinal injury.

A. Extravasation Injury

Peripheral Infusion: Dilute potassium to a concentration of ≤40 mEq/L and infuse at a maximum rate of 10 mEq/hr through a secure, large-bore IV.
Central Line Infusion: This is the preferred route for concentrations >60 mEq/L or infusion rates >10 mEq/hr to minimize risk of tissue damage.

Figure 1. Management of Potassium Extravasation. Immediate cessation of the infusion followed by local care can mitigate tissue injury.

B. Other Complications

Rebound Dyskalemia: Monitor serum potassium every 2–4 hours during and after IV therapy. Taper the infusion rate as levels approach 4.0 mEq/L to prevent overshoot hyperkalemia.
Insulin-Glucose Therapy: The standard dose is 10 units of regular insulin IV with 25 grams of dextrose. Check blood glucose every 30–60 minutes for at least 4 hours. Risk of hypoglycemia is higher in patients with renal impairment or malnutrition.
GI Safety with Binders: Avoid sodium polystyrene sulfonate in patients with bowel dysfunction or postoperative ileus due to risk of intestinal necrosis. Prefer newer agents like patiromer or sodium zirconium cyclosilicate for both rapid and chronic control.

Clinical Pearls

Always have an IV dextrose infusion immediately available at the bedside when administering insulin-glucose therapy for hyperkalemia.
Proactively educate nursing staff on the early signs of extravasation (pain, swelling, redness) to ensure prompt intervention.

3. ICU-Related Prophylaxis

Bundled prophylactic strategies against arrhythmias, venous thromboembolism (VTE), and catheter-related infections are crucial for maintaining stable potassium homeostasis and overall patient safety in the ICU.

A. Arrhythmia Prevention

Electrolyte Targets: Proactively maintain serum potassium at 4.0–4.5 mEq/L, magnesium >2.0 mg/dL, and ionized calcium in the upper-normal range.
QTc Monitoring: Obtain a 12-lead ECG every 12–24 hours if the patient is on known QT-prolonging drugs or after significant potassium shifts.

B. VTE Prophylaxis

Renal Dosing for VTE Prophylaxis
Renal Function	Recommended Agent	Rationale
CrCl >30 mL/min	Enoxaparin 40 mg SC daily	Standard dosing for most patients with adequate renal clearance.
CrCl <30 mL/min or Weight Extremes	Unfractionated Heparin 5,000 U SC q8h	Avoids accumulation of LMWH. Consider anti-Xa monitoring in obesity.

C. Catheter-Related Infection Prevention

Implement strict aseptic insertion and maintenance bundles, including full barrier precautions and chlorhexidine skin preparation.
Perform a daily review of line necessity and remove any unnecessary central or peripheral catheters promptly to reduce infection risk.

Clinical Pearls

A multidisciplinary electrolyte management bundle (targeting K+, Mg2+, Ca2+) reduces arrhythmic events more effectively than isolated potassium repletion alone.
Early and daily review for catheter removal is a high-impact intervention to prevent bloodstream infections, which can worsen metabolic and electrolyte instability.

4. Multidisciplinary Goals-of-Care Conversations

Aligning treatment intensity with patient values and prognosis is vital when considering invasive options like renal replacement therapy (RRT) for refractory dyskalemia.

A. Indications for RRT vs. Conservative Management

Renal Replacement Therapy (RRT): Indicated for life-threatening, uncontrolled hyperkalemia, especially with associated oliguria/anuria, severe metabolic acidosis, or uremic symptoms.
Conservative/Palliative Approach: May be appropriate for patients with a poor overall prognosis where the burden of invasive treatment outweighs the potential benefit.

B. Communication and Palliative Care

Palliative Considerations: Balance the goal of symptom relief against the discomfort and complications of dialysis (e.g., vascular access procedures, intradialytic hypotension). Engage palliative care specialists early.
Communication Frameworks: Utilize structured models like SPIKES (Setting, Perception, Invitation, Knowledge, Emotions, Strategy/Summary) to guide difficult conversations.
Documentation: Clearly document all goals-of-care decisions in the electronic health record to ensure continuity of care across all teams.

Clinical Pearls

Involve clinical pharmacists in family meetings to clearly explain medication-related risks, benefits, and alternatives to dialysis.
Initiate goals-of-care discussions within 24 hours of identifying refractory dyskalemia to proactively align treatment with patient wishes.

References

Clase CM, Carrero JJ, Ellison DH, et al. Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a KDIGO Controversies Conference. Kidney Int. 2020;97(1):42–61.
Dickerson RN. Fluids, Electrolytes, Acid-Base Disorders, and Nutrition Support. In: ACCP/SCCM Critical Care Pharmacy Prep Course. 2016.
Kim MJ, Valerio C, Knobloch GK. Potassium disorders: hypokalemia and hyperkalemia. Am Fam Physician. 2023;107(1):59–70.
Lumlertgul N, Peacock WF, Liu KD, et al. Management of hyperkalemia in the acutely ill patient. Crit Care. 2019;23(1):108.
Bell R. Hyperkalaemia on ICU UHL Critical Care Guideline. University Hospitals Leicester NHS Trust; 2023.
Abioye N, Caisley J, Bailey J. Treatment of Acute Hypokalaemia in Adults. UK Hospital Trust Guideline; 2022.
Palmer BF, Carrero JJ, Clegg DJ, et al. Clinical management of hyperkalemia. Mayo Clin Proc. 2021;96(3):744–762.
Weir MR, Bakris GL, Bushinsky DA, et al. Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors. N Engl J Med. 2015;372:211–221.
Packham DK, Rasmussen HS, Lavin PT, et al. Sodium zirconium cyclosilicate in hyperkalemia. N Engl J Med. 2015;372(3):222–231.
Harel Z, Harel S, Shah PS, et al. Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review. Am J Med. 2013;126(3):264.e9–264.e24.
Diercks DB, Shumaik GM, Harrigan RA, et al. Electrocardiographic manifestations: electrolyte abnormalities. J Emerg Med. 2004;27(2):153–160.
Truhlář A, Deakin CD, Soar J, et al. European Resuscitation Council Guidelines for Resuscitation 2015: Section 4. Cardiac arrest in special circumstances. Resuscitation. 2015;95:148–201.
Kovesdy CP, Matsushita K, Sang Y, et al. Serum potassium and adverse outcomes across kidney function: a CKD Prognosis Consortium meta-analysis. Eur Heart J. 2018;39(17):1535–1542.

2025 PACUPrep BCCCP Preparatory Course

Pulmonary

Participants 432

Supportive Care Measures and Monitoring in the Management of Potassium Disorders

Supportive Care Measures and Monitoring in the Management of Potassium Disorders

Learning Objective

1. Cardiac and Hemodynamic Monitoring

Key Monitoring Parameters

2. Prevention and Management of Iatrogenic Complications

A. Extravasation Injury

B. Other Complications

3. ICU-Related Prophylaxis

A. Arrhythmia Prevention

B. VTE Prophylaxis

C. Catheter-Related Infection Prevention

4. Multidisciplinary Goals-of-Care Conversations

A. Indications for RRT vs. Conservative Management

B. Communication and Palliative Care

References