1.0 Mechanical Ventilation Strategies

Lung-protective ventilation and adjunctive maneuvers are critical to reduce ventilator-induced lung injury (VILI) and the risk of ventilator-associated pneumonia (VAP).

1.1 Lung-Protective Ventilation (6 mL/kg Tidal Volume)

The cornerstone of managing pneumonia-related ARDS is limiting tidal volumes to 6 mL/kg of predicted body weight (PBW). This strategy has been shown to reduce mortality.

• Verify the delivered tidal volume against the calculated PBW at least once per nursing shift.
• Maintain a plateau pressure (P_plat) of ≤30 cm H₂O to minimize barotrauma.

1.2 PEEP Optimization & Recruitment Maneuvers

Positive end-expiratory pressure (PEEP) is titrated to improve oxygenation by preventing alveolar collapse. Recruitment maneuvers should be used cautiously only in cases of refractory hypoxemia after ensuring hemodynamic stability, as they can cause hypotension.

1.3 Head-of-Bed Elevation & Subglottic Secretion Drainage

These simple interventions form the backbone of VAP prevention bundles.

1.4 Sedation Minimization & Daily Spontaneous Breathing Trials (SBTs)

Protocols that minimize sedation and regularly assess readiness for extubation are crucial for reducing ventilator duration. Daily interruptions of sedative infusions (sedation vacations) paired with spontaneous breathing trials (SBTs) facilitate this process.

2.0 Hemodynamic & Organ Support

Early goal-directed fluid resuscitation and vasopressor use are essential to maintain end-organ perfusion without exacerbating pulmonary edema in patients with pneumonia-induced septic shock.

2.1 Fluid Resuscitation vs Vasopressors in Septic Shock

• Initial Resuscitation: Administer a 30 mL/kg crystalloid bolus within the first 3 hours for sepsis-induced hypotension.
• Ongoing Fluids: Use dynamic indices of fluid responsiveness (e.g., pulse pressure variation, passive leg raise) to guide subsequent fluid administration.
• Vasopressors: Initiate norepinephrine as the first-line agent to achieve a mean arterial pressure (MAP) of ≥65 mm Hg. Add vasopressin as a second-line agent if norepinephrine requirements are escalating.

2.2 Targeted Hemodynamic Goals (MAP, ScvO₂)

Monitoring hemodynamic targets helps ensure resuscitation is adequate.

• MAP: Target 65–70 mm Hg in most patients. Consider a higher target of 75–80 mm Hg in patients with a history of chronic hypertension.
• Perfusion Markers: A central venous oxygen saturation (ScvO₂) >70% and lactate clearance >10% over 2 hours are strong indicators of adequate tissue perfusion and oxygen delivery.

3.0 ICU Complication Prevention

Standardized prophylaxis for thromboembolism, stress ulcers, and catheter-related infections is a key component of high-quality critical care and reduces ICU-acquired morbidity.

3.1 VTE Prophylaxis Protocols

Critically ill patients are at high risk for venous thromboembolism (VTE). Pharmacologic prophylaxis is standard unless a high bleeding risk exists.

• Pharmacologic: Enoxaparin 40 mg SC once daily or unfractionated heparin 5,000 units SC every 8–12 hours.
• Mechanical: Use intermittent pneumatic compression devices when pharmacologic agents are contraindicated (e.g., active bleeding, severe thrombocytopenia).

3.2 Stress Ulcer Prophylaxis (SUP)

SUP is indicated for patients at high risk of clinically significant gastrointestinal bleeding, primarily those with coagulopathy or on prolonged mechanical ventilation.

3.3 Catheter Care Bundles to Prevent CRBSI

Central line-associated bloodstream infections (CLABSIs) are prevented through meticulous adherence to insertion and maintenance bundles.

• Insertion: Use maximal barrier precautions, chlorhexidine skin antisepsis, and ultrasound guidance to minimize attempts.
• Maintenance: Perform daily review of line necessity, use chlorhexidine-impregnated dressings, and ensure aseptic technique for all hub access.

3.4 Glycemic Control & Nutrition Support

• Glycemic Control: Target a blood glucose range of 140–180 mg/dL using a validated insulin infusion protocol. This balances the risk of infection from hyperglycemia against the risk of hypoglycemia.
• Nutrition: Initiate enteral nutrition within 24–48 hours to maintain gut integrity. Reserve parenteral nutrition for patients with a contraindication to enteral feeding.

4.0 Iatrogenic Complication Management

Vigilant monitoring for drug-induced harm, such as nephrotoxicity and C. difficile infection, is essential to prevent therapy-related complications.

4.1 Nephrotoxicity Monitoring

Antibiotics like vancomycin and aminoglycosides are common causes of acute kidney injury (AKI) in the ICU. Careful dosing and monitoring are required.

Always adjust dosing for renal replacement therapy (RRT) and check serum creatinine daily in patients receiving these agents.

4.2 Clostridioides difficile Risk Mitigation

Prolonged use of broad-spectrum antibiotics is a major risk factor for C. difficile infection (CDI).

• Antibiotic Stewardship: De-escalate or narrow antibiotic therapy as soon as culture and sensitivity data are available.
• CDI Therapy: First-line treatment is oral fidaxomicin (200 mg BID for 10 days).
• Refractory CDI: Reserve fecal microbiota transplantation (FMT) for patients with multiple recurrences.

5.0 Goals-of-Care & Ethical Considerations

Early and structured discussions about prognosis and patient values are critical to ensure that intensive care treatments align with what is most important to the patient.

5.1 Indications for Invasive Modalities

Decisions to initiate or continue highly invasive therapies like mechanical ventilation or extracorporeal membrane oxygenation (ECMO) must consider the potential for recovery. These should be reserved for patients with reversible respiratory failure where less invasive supports have failed. Factors such as age, major comorbidities, and pre-illness functional status are key to these discussions.

5.2 Multidisciplinary Family Conferences

Regularly scheduled family conferences involving the core clinical team (critical care, nursing, respiratory therapy) and consultants (infectious diseases, palliative care) are essential. These meetings provide a forum to explain the clinical situation, establish a shared understanding of the prognosis, and document patient preferences, advance directives, and code status.

5.3 Palliative Care Integration

Palliative care should be integrated early, not just at the end of life. This specialized service focuses on comprehensive symptom management (pain, dyspnea, anxiety), provides psychosocial and spiritual support to patients and families, and facilitates complex advance care planning discussions, especially when the prognosis is uncertain or the burden of treatment is high.

6.0 Monitoring & Quality Indicators

Continuous surveillance of clinical trends and process metrics is fundamental to driving quality improvement and ensuring adherence to best practices in the ICU.

6.1 Serial Chest Imaging & Laboratory Trends

• Chest Radiographs: Obtain serial imaging every 48–72 hours or as clinically indicated by worsening respiratory status, not as a daily routine.
• Procalcitonin: Monitor trends to help guide antibiotic de-escalation. A significant decrease can support shortening the duration of therapy, but decisions must always be made in the full clinical context.

6.2 Performance Metrics (VAP Rates, Bundle Compliance)

Tracking key performance indicators (KPIs) helps identify gaps in care and sustain high performance.

• Outcome Measures: Track VAP incidence per 1,000 ventilator-days.
• Process Measures: Audit compliance with care bundles for the ventilator, VTE/SUP prophylaxis, and central line maintenance.
• Feedback: Use real-time unit-level dashboards to display adherence rates, fostering accountability and a culture of safety.