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Neurology 111
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Lesson 3,
Topic 9
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Summary and References
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Myasthenic crisis is an acute exacerbation of muscle weakness in myasthenia gravis leading to respiratory failure. Emergency and critical care pharmacists play a vital role through prompt recognition, airway protection, individualized pharmacotherapy, and multidisciplinary care coordination. Optimizing therapy while avoiding medications exacerbating neuromuscular weakness is imperative for favorable outcomes.
References
- Silvestri NJ, Wolfe GI. Myasthenia gravis. Semin Neurol. 2012;32(3):215-226.
- Howard JF Jr. Clinical Overview of MG. Myasthenia Gravis Foundation of America. https://myasthenia.org. Accessed July 2023.
- Gajdos P, Chevret S, Clair B, Tranchant C, Chastang C. Clinical trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis. Ann Neurol. 1997 Dec;42(6):789-96.
- Cohen JA, Focus on myasthenic crisis. N Engl J Med. 1997;337:510-512.
- Gajdos P, Chevret S, Toyka K. Intravenous immunoglobulin for myasthenia gravis. Cochrane Database Syst Rev. 2012 Dec 12;12:CD002277.
- Sanders DB, Wolfe GI, Benatar M, et al. International consensus guidance for management of myasthenia gravis: Executive summary. Neurology. 2016;87(4):419-425.
- Huda S, Al-Busaidi R, Alrawahi A, et al. Myasthenic Crisis. [Updated 2022 Jul 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.