Allison Clemens
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2025 PACUPrep BCCCP Preparatory Course Ventricular Arrhythmias and Sudden Cardiac Death Prevention Secondary Prevention of Ventricular Tachyarrhythmias and Sudden Cardiac Death

Lesson 14, Topic 5

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Secondary Prevention of Ventricular Tachyarrhythmias and Sudden Cardiac Death

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Comprehensive Post-Acute Management and SCD Prevention in Ventricular Arrhythmias

Lesson Objective

Develop a comprehensive plan for post-acute management of ventricular arrhythmias, including sudden cardiac death prevention, device therapy, and transition to the next level of care.

I. Implantable Cardioverter-Defibrillator (ICD) Therapy

ICDs are the cornerstone of both secondary and primary prevention of sudden cardiac death. Appropriate patient selection and timing optimize benefit while minimizing risks.

A. Indications and Patient Selection

Secondary prevention: survivors of sustained VT/VF arrest not due to reversible causes (e.g., acute ischemia, electrolyte disturbances).
Primary prevention: LVEF ≤35% after ≥3 months of optimal guideline-directed medical therapy (GDMT) in ischemic or nonischemic cardiomyopathy, NYHA II–III symptoms.
Additional considerations: arrhythmia burden, projected survival (>1 year), comorbidities, patient values and goals.

B. Timing and Guideline Recommendations

Post-MI: wait ≥40 days before primary prevention ICD to allow LVEF recovery with GDMT.
Post-revascularization: wait ≥90 days before reassessment for ICD candidacy.
Guideline classes: Class I for secondary prevention and primary prevention with LVEF ≤35%; Class IIa for select nonischemic cardiomyopathy patients.

C. Procedural Considerations and Follow-Up

Pre-implant: exclude active infection, plan venous access, manage anticoagulation.
Device choice: transvenous ICD when pacing or ATP is needed; subcutaneous ICD for patients without pacing requirements or high infection risk.
Programming: set detection zones, enable antitachycardia pacing for monomorphic VT, prolong detection intervals to reduce inappropriate therapies.
Post-implant follow-up: in-office interrogation at 2–6 weeks, remote monitoring setup, regular interrogation every 3–6 months, adjust programming based on therapy delivery.

Key Pearls

ICDs do not benefit patients with VT/VF from reversible causes or life expectancy <1 year due to noncardiac disease.
Remote monitoring reduces inappropriate shocks and identifies lead/device issues early.

II. Pharmacotherapy: Transition to Oral Antiarrhythmics and Guideline-Directed Medical Therapy

Transitioning from IV to oral antiarrhythmics and optimizing GDMT are essential to maintain rhythm control and reduce SCD risk long term.

A. Conversion from IV to Oral Antiarrhythmic Therapy

Principles:

Provide therapeutic overlap accounting for half-lives and bioavailability.
Adjust dosing for hepatic or renal dysfunction.
Monitor ECG for QRS widening and QT prolongation; check electrolytes and drug interactions.

Oral Antiarrhythmic Agents
Drug	Mechanism	Oral Dosing	Monitoring	Pearls
Amiodarone	Class III K+ blockade; I, II, IV ant.	Loading: 400 mg TID ×7 days → 200 mg BID ×7 days → 200 mg daily	TSH, LFTs q6 mo; CXR annually; ECG	Overlap IV ≥24 h; watch interactions
Sotalol	Nonselective β-blocker + Class III	Start 80 mg BID; ↑ by 40–80 mg every 3 days to QT <500 ms	QTc, CrCl, HR, BP	Inpatient telemetry initiation
Mexiletine	Class IB Na+ blockade	150–200 mg TID	LFTs; neuro exam for tremor	Avoid abrupt stop; GI/CNS side effects

B. Guideline-Directed Medical Therapy for SCD Prevention

Principles:

Initiate and up-titrate GDMT promptly after stabilization.
Target doses based on landmark trials; monitor BP, renal function, electrolytes, heart rate.

Key Agents:

Beta-blockers (Metoprolol, Carvedilol, Bisoprolol): reduce mortality, arrhythmia recurrence. Titrate to HR 55–60 bpm.
ACE inhibitors/ARBs/ARNI (Lisinopril, Valsartan, Sacubitril/Valsartan): attenuate remodeling; require washout (ACEi→ARNI 36 h).
MRAs (Spironolactone, Eplerenone): reduce fibrosis; check K+ within 3 days and weekly ×1 month.
SGLT2 inhibitors (Dapagliflozin, Empagliflozin): reduce HF hospitalizations, potential arrhythmias; counsel on hydration and genital hygiene.

Key Pearls

Titrate slowly to avoid hypotension and decompensation.
Check renal function and K+ before every uptitration.

III. Catheter Ablation for Recurrent, Drug-Refractory VT

Catheter ablation reduces VT recurrence and ICD therapies in patients with monomorphic scar-related VT who fail or cannot tolerate ≥2 antiarrhythmic drugs.

A. Indications

Recurrent monomorphic VT despite ≥2 antiarrhythmics.
VT storm (≥3 VT/VF episodes in 24 h) or frequent ICD shocks.

B. Procedural Overview and Patient Preparation

Electroanatomical mapping: identify substrate via voltage mapping or activation mapping during induced VT.
Support: consider mechanical circulatory support (e.g., Impella, ECMO) in patients with poor hemodynamics.

C. Post-Ablation Management and Follow-Up

Continue antiarrhythmics for 1–3 months post-procedure; taper based on recurrence.
Inpatient monitoring for recurrence, pericardial complications.
Long-term: device interrogation, ECGs, GDMT optimization.

Key Pearl

Ablation reduces ICD shocks but does not replace the need for ICD in most patients.

IV. Mitigation of Post-ICU Syndrome

Survivors of critical arrhythmia events are at risk for PICS, characterized by physical, cognitive, and psychological impairments. Early mitigation strategies improve recovery.

A. Risk Stratification

High risk: prolonged mechanical ventilation, multiple vasopressors, prolonged delirium, baseline frailty or cognitive impairment.

B. ABCDEF Bundle

The ABCDEF bundle is a multicomponent strategy to reduce ICU-acquired complications:

Assess, Prevent,
Manage Pain

Both Spontaneous
Awakening Trials &
Breathing Trials

Choice of
Analgesia and
Sedation

Delirium: Assess,
Prevent, Manage

Early Mobility
and Exercise

Family Engagement
and Empowerment

Figure 1: The ABCDEF Bundle. A structured approach to optimize ICU patient care and mitigate Post-ICU Syndrome.

C. Structured Rehabilitation Programs

In-hospital PT/OT for muscle strength and endurance
Post-discharge cardiac rehabilitation with cognitive and psychological support

Key Pearl

Early mobilization and minimal sedation are critical to prevent ICU-acquired weakness and delirium.

V. Medication Reconciliation and Patient Education

A thorough med rec and patient education plan ensures continuity of care, optimizes adherence, and prepares patients for device interactions and lifestyle changes.

A. Medication Reconciliation Process

Compare pre-admission, in-hospital, and discharge lists.
Identify omissions, duplications, dosing errors, and interactions (especially QT-prolonging drugs).

B. Patient Education on Device Care

ICD shock recognition and response plan.
Magnet application, device alerts, and precautions (MRI, electrocautery).
Remote monitoring setup and troubleshooting.

C. Lifestyle Modifications and Follow-Up Planning

Diet: low-sodium, heart-healthy.
Exercise: tailored to arrhythmia risk and device therapy.
Adherence tools: pillboxes, reminders.
Follow-up schedule: cardiology visits, device checks, labs, echocardiograms.

Key Pearl

Instruct patients to report ICD shocks, syncope, or new arrhythmic symptoms immediately.

References

Al-Khatib SM et al. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and SCD Prevention. Circulation. 2018;138:e272–e391.
Ray L, Geier C, DeWitt KM. Pathophysiology and Treatment of Ventricular Arrhythmias. Am J Health-Syst Pharm. 2023;80(17):1123–1136.
Wilkoff BL et al. 2015 HRS/EHRA Expert Consensus on ICD Programming. J Arrhythmia. 2016;32:1–28.
Yancy CW et al. 2017 ACC/AHA HFSA Update of Heart Failure Guidelines. Circulation. 2017;136:e137–e161.
Ortiz M et al. PROCAMIO Study: Procainamide vs Amiodarone for Stable VT. Eur Heart J. 2017;38(17):1329–1335.
Kudenchuk PJ et al. Amiodarone for Out-of-Hospital Cardiac Arrest. N Engl J Med. 1999;341(12):871–878.
Dorian P et al. Amiodarone vs Lidocaine for Shock-Resistant VF. N Engl J Med. 2002;346(12):884–890.
Tisdale JE. Drug-Induced QT Prolongation and Torsades de Pointes. Can Pharm J. 2016;149(3):139–152.
Topjian AA et al. 2020 AHA Guidelines for Post-ICU Syndrome Mitigation. Circulation. 2020;142(16 Suppl 2):S469–S523.

2025 PACUPrep BCCCP Preparatory Course

Pulmonary

Participants 432

Secondary Prevention of Ventricular Tachyarrhythmias and Sudden Cardiac Death

Comprehensive Post-Acute Management and SCD Prevention in Ventricular Arrhythmias

Lesson Objective

I. Implantable Cardioverter-Defibrillator (ICD) Therapy

A. Indications and Patient Selection

B. Timing and Guideline Recommendations

C. Procedural Considerations and Follow-Up

II. Pharmacotherapy: Transition to Oral Antiarrhythmics and Guideline-Directed Medical Therapy

A. Conversion from IV to Oral Antiarrhythmic Therapy

Principles:

B. Guideline-Directed Medical Therapy for SCD Prevention

Principles:

Key Agents:

III. Catheter Ablation for Recurrent, Drug-Refractory VT

A. Indications

B. Procedural Overview and Patient Preparation

C. Post-Ablation Management and Follow-Up

IV. Mitigation of Post-ICU Syndrome

A. Risk Stratification

B. ABCDEF Bundle

C. Structured Rehabilitation Programs

V. Medication Reconciliation and Patient Education

A. Medication Reconciliation Process

B. Patient Education on Device Care

C. Lifestyle Modifications and Follow-Up Planning

References