1. Introduction: Goals of Recovery and Transition

As delirium resolves, the clinical focus shifts to a systematic de-escalation of deliriogenic therapies, promotion of neurocognitive recovery, and meticulous planning for safe care transitions. The integration of early rehabilitation and comprehensive medication review is critical to minimizing polypharmacy, shortening the length of stay, and reducing the incidence and severity of post-ICU syndrome.

High-Yield Points

• Target the reduction of sedatives and antipsychotics once the patient is calm, CAM-ICU–negative, and consistently following commands.
• Initiate planning for discharge medications from the first day in the ICU to avoid last-minute, potentially erroneous changes.

2. Weaning and De-escalation Protocols

Successful de-escalation relies on objective criteria and stepwise algorithms to taper sedatives and antipsychotics, which helps prevent iatrogenic withdrawal syndromes and rebound delirium.

2.1 Criteria for Tapering

• Hemodynamic stability without escalating vasopressor requirements.
• Absence of agitation or psychosis for at least 48 hours.
• Patient is awake, easily arousable, and able to follow simple commands (RASS score of –1 to 0).

2.2 Stepwise Withdrawal Algorithm

• Reduce continuous sedative infusions by 10–25% every 6–12 hours, provided the RASS score remains within the target range (–1 to 0).
• Halve intravenous benzodiazepine infusion rates over 24 hours; convert to as-needed (PRN) oral lorazepam for breakthrough symptoms.
• Decrease enteral antipsychotics (e.g., haloperidol) by 50% every 1–2 days before complete discontinuation.

2.3 Monitoring for Withdrawal Syndromes

• Closely observe for signs of withdrawal, including tachycardia, hypertension, diaphoresis, tremor, and agitation.
• If withdrawal signs emerge, return to the last tolerated dose and slow the subsequent taper rate by 50%.
• Routinely check electrolytes (especially magnesium and phosphate) and ensure analgesia is optimized.

3. Intravenous-to-Enteral Medication Conversion

Transitioning from intravenous (IV) to oral or enteral formulations is a key step in de-escalation. This process requires careful assessment of gastrointestinal (GI) function, adjustment for altered bioavailability, and close monitoring of the clinical response.

3.1 Assessing Enteral Access & GI Function

• Confirm feeding tube placement and patency before administration.
• Assess GI tolerance by checking gastric residual volumes, auscultating for bowel sounds, and performing an abdominal exam.
• Consider using prokinetic agents (e.g., metoclopramide 10 mg QID) for patients with evidence of delayed gastric emptying.

3.2 Bioavailability & Conversion Ratios

4. Mitigation of Post-ICU Syndrome (PICS)

Post-ICU syndrome (PICS), a constellation of physical, cognitive, and psychological impairments, affects over half of ICU survivors. Early and consistent application of the ABCDEF(F) bundle, combined with multidisciplinary rehabilitation, is the most effective strategy to reduce long-term sequelae.

4.1 Definition & Risk Stratification

• PICS encompasses ICU-acquired weakness, cognitive deficits (memory, attention), and psychological issues like depression, anxiety, and PTSD.
• Risk factors include delirium duration >4 days, advanced age, and pre-existing comorbidities. The PRE-DELIRIC score can help identify high-risk patients early.

4.2 The ABCDEF(F) Bundle

4.3 Early Rehabilitation

• Initiate mobilization within 48 hours of ICU admission, once the patient is hemodynamically stable.
• Provide cognitive stimulation through orientation boards, simple tasks, and regular communication.
• Offer psychological support via ICU diaries, structured visitation, and family involvement.

5. Medication Reconciliation and Discharge Planning

A thorough medication reconciliation process is vital to prevent medication errors, while comprehensive patient education and timely follow-up are proven strategies to reduce hospital readmissions.

5.1 Inpatient Pharmacotherapy Review

• Proactively discontinue potentially deliriogenic drugs, including anticholinergics, high-dose opioids, and benzodiazepines.
• Reinstate essential home medications (e.g., for cardiovascular or endocrine conditions) as the patient returns to their clinical baseline.
• Clearly document the indication and intended duration for all medications initiated in the ICU.

5.2 Patient & Caregiver Education

• Provide clear written and verbal instructions on all new, resumed, and discontinued medications.
• Use the “teach-back” method to confirm understanding of the medication regimen.
• Highlight key side effects and monitoring parameters for high-risk medications.

5.3 Coordination with Outpatient Teams

• Send a concise discharge summary, including a finalized medication list, to the primary care provider and relevant specialists.
• Engage community pharmacy services to provide adherence aids like pill boxes or blister packs for complex regimens.

6. Handoff Tools and Checklists

Standardized handoff tools are essential to ensure that critical information—such as delirium history, sedation weaning status, and follow-up needs—is transferred reliably between clinicians and care settings.

6.1 EHR Summaries and Communication

• Utilize EHR templates that auto-populate sedation history, delirium episodes, and weaning progress.
• Highlight pending medication adjustments and specific monitoring requirements.
• Apply the SBAR (Situation, Background, Assessment, Recommendation) format for all verbal and written handoffs to ensure structured, concise communication.

6.2 Quality Metrics

• Track hospital readmissions related to medication errors or delirium recurrence.
• Monitor functional and cognitive outcomes at 30 and 90 days post-discharge to assess the effectiveness of transition-of-care processes.