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PACULit Literature Updates August 2025: Pediatrics

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  • Allison Clemens
  • April
  • ababaabhay
  • achoi2392
  • adhoward1
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Prehospital pain medication disparities among pediatric trauma patients transported to a single Level I center

Prehospital pain medication disparities among pediatric trauma patients transported to a single Level I center

Hughes Garza H, Comer-HaGans D, Bradford JM, et al. J Trauma Acute Care Surg. 2025 Jul;:-. doi: 10.1097/TA.0000000000004711. PMID: 40671198.

Introduction

Effective pain management in pediatric trauma patients during prehospital care is critical to reduce physiological stress and improve outcomes. However, disparities in analgesic administration based on race and ethnicity have been increasingly recognized as a significant concern in emergency medical services (EMS) systems. This retrospective cohort study investigates these disparities among pediatric trauma patients transported to a single Level I trauma center over a seven-year period, aiming to elucidate factors contributing to unequal pain treatment and identify potential interventions.

Despite a high prevalence of documented pain among pediatric trauma patients, prehospital analgesic administration remains suboptimal. Understanding the influence of demographic and clinical variables on pain medication use is essential to guide equitable and effective pain management strategies in the prehospital setting.

Study Overview

Study Type: Retrospective cohort study analyzing prehospital records from August 2015 to July 2022

Population: 2,308 pediatric trauma patients (age 0-18 years) transported directly from the scene to a single Level I trauma center

Intervention: Assessment of prehospital pain medication administration and associated demographic and clinical factors

Outcomes: Receipt of any prehospital pain medication; disparities by race and ethnicity after adjustment for clinical need and other confounders

Additional Factors Assessed: Age, socioeconomic status, language barriers, prehospital vascular access, injury mechanism (e.g., motor vehicle collision), and patient/family preferences.

Key Findings

  • 82% of patients reported prehospital pain; 67% had pain scores 6460;/10, yet only 35% received pain medication prehospital.
  • Black patients were 23% less likely to receive pain medication (adjusted relative rate [aRR] 0.77; 95% CI 0.71-0.84) compared to White patients.
  • Hispanic patients were 20% less likely to receive pain medication (aRR 0.80; 95% CI 0.74-0.87) compared to White patients.
  • Factors linked to both minority race/ethnicity and lower analgesic use included younger age, lower socioeconomic status, language barriers, lack of vascular access, and motor vehicle collision involvement.
  • Overall prehospital pain medication administration increased and disparities decreased over the study period, but inequities persist.

Evidence Synthesis

The findings align with prior research demonstrating racial and ethnic disparities in prehospital pain management among pediatric trauma patients. Hughes Garza et al. provide robust evidence from a large, single-center cohort highlighting persistent inequities despite adjustment for clinical need and other confounders.

Supporting Studies

  • Hewes et al., 2022: National database analysis confirming lower likelihood of prehospital analgesic administration in Black children, indicating systemic disparities (PMID: 2).
  • Nishijima et al., 2020: Prospective multicenter study found no significant adjusted racial/ethnic disparities in EMS opioid administration, suggesting variability by setting and methodology (PMID: 3).
  • Johnson et al., 2018: Air medical transport data analysis showed no adjusted differences in analgesic use by race/ethnicity, highlighting transport modality as a potential modifier (PMID: 4).

Summary Table of Key Studies

Study Design Population Findings on Disparities Clinical Relevance
Hughes Garza et al. (2025) Retrospective cohort 2,308 pediatric trauma patients, single Level I center Black and Hispanic patients less likely to receive pain meds after adjustment Highlights persistent disparities; targets for intervention
Hewes et al. (2022) National database study Large pediatric EMS cohort Black children less likely to receive analgesics Supports systemic disparity concerns
Nishijima et al. (2020) Prospective multicenter EMS pediatric patients No significant adjusted racial/ethnic disparities Suggests setting and methodology impact findings
Johnson et al. (2018) Air medical transport retrospective Injured children transported by air EMS No adjusted disparities found Transport modality may influence analgesic equity
Evidence Integration

This body of evidence underscores that while overall pediatric prehospital pain management is frequently inadequate, racial and ethnic disparities persist in many settings. Variability in findings across studies suggests that local EMS protocols, transport modalities, and study designs influence observed disparities. Interventions addressing implicit bias, provider education, and protocol standardization are essential to promote equitable analgesic administration.

Clinical Implications

  • EMS systems should implement standardized pain assessment and analgesic protocols to reduce variability and disparities in pediatric pain management.
  • Training programs must address implicit bias and cultural competency to improve equitable care delivery.
  • Expand use of non-invasive analgesic routes (intranasal, oral) to overcome barriers related to vascular access and language.
  • Promote diversity in EMS workforce hiring to enhance cultural sensitivity and trust.

Strengths & Limitations

Strengths Limitations
Large sample size with detailed clinical and demographic data Single-center design limits generalizability
Adjustment for multiple confounders including clinical need and preferences Retrospective design subject to documentation and selection bias
Long study period allowing trend analysis Potential unmeasured confounders such as EMS provider-level factors
Comprehensive assessment of socioeconomic and language barriers Limited data on pain medication dosing and timing

Future Directions

Prospective multicenter studies are needed to validate these findings across diverse EMS systems and geographic regions. Research should focus on evaluating targeted interventions such as implicit bias training, protocol standardization, and expanded analgesic options to reduce disparities. Additionally, exploring EMS provider perspectives and system-level barriers will inform effective strategies to optimize equitable pediatric pain management.

Conclusion

Prehospital pain management for pediatric trauma patients remains suboptimal and marked by significant racial and ethnic disparities, underscoring the urgent need for targeted interventions to ensure equitable analgesic care.

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References

  1. Hughes Garza H, Comer-HaGans D, Bradford JM, Brown CV, Naiditch J, Lawson KA. Prehospital pain medication disparities among pediatric trauma patients transported to a single Level I center. J Trauma Acute Care Surg. 2025 Jul;:-. doi: 10.1097/TA.0000000000004711. PMID: 40671198.
  2. Hewes HA, Dai M, Mann NC, Baca T, Taillac P. Prehospital Pain Management: Disparity By Age and Race. Prehosp Emerg Care. 2022;22(2):189-197.
  3. Nishijima DK, Tancredi DJ, Adelgais KM, Chadha K, Chang TP, Harris MI, et al. Impact of Race and Ethnicity on Emergency Medical Services Administration of Opioid Pain Medications for Injured Children. Ann Emerg Med. 2020;64(1):55-61.
  4. Johnson TJ, Schultz BR, Guyette FX. Characterizing analgesic use during air medical transport of injured children. Air Med J. 2018;37(4):531-538.