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Key Recommendations for Management of Pediatric Sepsis
| Guideline/ Source | Key Recommendations | Level of Evidence | Strength of Recommendation |
| Surviving Sepsis Campaign Guidelines (2021) | Administer antimicrobials within 1 hour of sepsis recognition | Moderate | Strong |
| Surviving Sepsis Campaign Guidelines (2021) | Provide fluid resuscitation with 20 mL/kg crystalloid boluses over 30-60 mins to reverse hypotension | Low | Weak |
| Surviving Sepsis Campaign Guidelines (2021) | Begin vasoactive agents if fluid refractory shock persists after 40-60 mL/kg | Low | Weak |
| Surviving Sepsis Campaign Guidelines (2021) | Target threshold MAP of 5th percentile for age | Moderate | Strong |
| American College of Critical Care Medicine Guidelines (2009) | Use protocol-driven management approach with sepsis bundles | Low | Strong |
| American College of Critical Care Medicine Guidelines (2009) | Measure serum lactate level; normalize lactate <2 mmol/L | Moderate | Strong |