1. Epidemiology and Incidence in Critical Illness

Acid–base disturbances are among the most common laboratory abnormalities in the intensive care unit (ICU). They frequently manifest as complex mixed disorders and are strongly correlated with patient outcomes, including mortality and length of stay.

Prevalence and Mortality

• Prevalence: Up to 70% of ICU patients exhibit mixed acid–base disorders. Single disturbances, such as metabolic acidosis or respiratory alkalosis, are identified in 30–50% of admissions.
• Mortality Correlation: The severity of the disturbance is directly linked to risk. An admission arterial pH below 7.20 can double the risk of ICU mortality compared to a pH in the normal range. Furthermore, conditions like non-anion gap metabolic acidosis are predictive of prolonged mechanical ventilation and the need for renal replacement therapy (RRT).

Common Etiologies in the ICU

1. Sepsis: Leads to lactic acidosis through a combination of tissue hypoperfusion and direct mitochondrial dysfunction.
2. Shock States (Cardiogenic, Hypovolemic): Often cause a mixed acidosis due to impaired CO₂ elimination (respiratory component) and poor hydrogen ion (H⁺) clearance (metabolic component).
3. Acute Kidney Injury (AKI): Results in the accumulation of uremic organic acids and a failure to regenerate bicarbonate (HCO₃⁻).
4. Toxin Ingestions: Classic causes of high-anion gap metabolic acidosis include ethylene glycol, methanol, and salicylates.

2. Acid–Base Physiology Overview

The body maintains a tightly controlled physiologic pH between 7.35 and 7.45. This delicate balance is governed by three primary mechanisms: chemical buffering systems, respiratory regulation of carbon dioxide, and renal handling of bicarbonate and hydrogen ions.

• Extracellular Buffers: The bicarbonate/carbonic acid system is the most important extracellular buffer, governed by the Henderson–Hasselbalch equation: pH = pKₐ + log([HCO₃⁻] / [0.03 × PaCO₂]). Non-bicarbonate buffers like hemoglobin and plasma proteins contribute about 40% of the total buffering capacity.
• Respiratory Regulation: The lungs can alter pH within minutes. Increased minute ventilation blows off CO₂, decreasing PaCO₂ and raising pH. Conversely, hypoventilation retains CO₂, lowering pH. Conditions causing V/Q mismatch, like ARDS or COPD, impair this response.
• Renal Regulation: This is a slower process, taking hours to days. The kidneys regulate acid-base balance by: (1) reclaiming filtered HCO₃⁻ in the proximal tubule, (2) generating new HCO₃⁻ via ammoniagenesis, and (3) secreting H⁺ in the distal tubule.

3. Pathophysiology of Primary Disorders

Acid–base disorders are classified by the primary disturbance (metabolic or respiratory) and the direction of the pH change (acidosis or alkalosis). A systematic approach is crucial for accurate diagnosis.

A. Metabolic Acidosis

Defined by a primary decrease in serum HCO₃⁻, metabolic acidosis is broadly classified based on the anion gap.

Compensation: The expected respiratory compensation can be estimated using Winter’s formula: Expected PaCO₂ ≈ (1.5 × HCO₃⁻) + 8 ± 2.

B. Metabolic Alkalosis

Characterized by a primary increase in serum HCO₃⁻. Classification is based on urinary chloride, which helps determine the underlying cause and guide therapy.

• Chloride-Responsive (Urine Cl⁻ < 20 mEq/L): Caused by loss of chloride-rich fluids (e.g., vomiting, NG suction) or diuretic use. Treatment involves volume repletion with isotonic saline and potassium chloride (KCl).
• Chloride-Unresponsive (Urine Cl⁻ > 20 mEq/L): Associated with states of mineralocorticoid excess (e.g., hyperaldosteronism). Treatment targets the underlying cause, often involving mineralocorticoid blockade (spironolactone) or acetazolamide to promote bicarbonate excretion.

C. Respiratory Acidosis

Caused by alveolar hypoventilation, leading to an increase in PaCO₂ and a drop in pH. The degree of metabolic compensation distinguishes acute from chronic forms.

• Acute: For every 10 mm Hg increase in PaCO₂, HCO₃⁻ rises by 1 mEq/L.
• Chronic: For every 10 mm Hg increase in PaCO₂, HCO₃⁻ rises by 3–4 mEq/L due to renal compensation.

Management focuses on improving ventilation by treating the underlying cause (e.g., reversing sedation, bronchodilators for COPD) or providing mechanical support.

D. Respiratory Alkalosis

Caused by alveolar hyperventilation, leading to a decrease in PaCO₂ and a rise in pH. It is often a sign of an underlying systemic problem like pain, anxiety, sepsis, or hypoxemia. Management is directed at treating the trigger rather than the alkalosis itself.

4. Impact of Chronic Diseases

Pre-existing chronic conditions, particularly CKD and COPD, significantly alter a patient’s baseline acid-base status and their response to acute insults.

A. Chronic Kidney Disease (CKD)

In CKD, the kidneys’ ability to excrete the daily acid load and regenerate bicarbonate is impaired. This leads to a chronic, often asymptomatic, metabolic acidosis. This baseline state means that an acute acidotic insult can cause a more profound and rapid drop in pH. Early oral bicarbonate supplementation may slow CKD progression.

B. Chronic Obstructive Pulmonary Disease (COPD)

Patients with severe COPD have chronic respiratory acidosis (hypercapnia) due to impaired CO₂ elimination. The kidneys compensate by retaining bicarbonate, leading to a baseline serum HCO₃⁻ that is often 28–34 mEq/L. During an acute exacerbation, they develop an acute-on-chronic respiratory acidosis. A key pitfall is the rapid correction of hypercapnia with mechanical ventilation, which can precipitate a severe post-hypercapnic metabolic alkalosis, potentially causing seizures.

5. Social Determinants of Health (SDoH)

Socioeconomic factors, medication access, health literacy, and nutrition can significantly influence a patient’s risk for developing severe acid-base disorders and their outcomes.

• Medication Access & Adherence: Gaps in insurance or pharmacy access can prevent patients with CKD or COPD from receiving necessary medications, leading to poorly controlled disease and a higher risk of acute decompensation.
• Health Literacy: A limited understanding of symptoms like dyspnea or confusion can lead to delayed presentation to the hospital, by which time the acid-base disturbance is more severe.
• Nutrition & Socioeconomic Factors: Malnutrition, common in lower socioeconomic groups, reduces the synthesis of buffer proteins. Diets high in processed foods can contribute to hyperchloremic states, while high animal protein intake increases the chronic dietary acid load.