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2025 PACUPrep BCCCP Preparatory Course Open Fracture Antibiotics Diagnostics and Classification of Open Fractures

Lesson 100, Topic 2

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Diagnostics and Classification of Open Fractures

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Learning Objectives

After completing this chapter, you will be able to:

Apply diagnostic and classification criteria to assess an open fracture and guide initial management.
Describe the clinical manifestations and signs used in the initial diagnosis of open fracture and associated contamination.
Interpret imaging and laboratory results to confirm tissue involvement and infection risk.
Utilize the Gustilo-Anderson classification system to stratify open fracture severity and guide antibiotic selection and surgical urgency.

1. Clinical Presentation and Assessment

Rapid, systematic evaluation of the wound and patient status is essential to identify open fractures, assess contamination, and detect neurovascular compromise. A thorough assessment forms the basis for classification and initial management.

Mechanism and Inspection

The history provides clues to the energy of the injury and potential contaminants. High-energy mechanisms include motor vehicle accidents, falls from height, and penetrating trauma. Farm or aquatic exposures carry unique microbiological risks.

Wound Inspection: Carefully measure the wound’s length and depth. Note any exposed bone, joint violation, or gross contamination with soil, clothing fibers, or other foreign bodies.
Soft-Tissue Viability: Assess the surrounding tissue color and capillary refill to gauge perfusion and viability.
Neurovascular Exam: Palpate distal pulses and compare them bilaterally. A comprehensive evaluation of motor function and light touch sensation in all relevant dermatomes is critical.

Immediate Management Steps

Irrigate the wound surface with sterile isotonic saline. Avoid aggressive, high-pressure jets which can drive contaminants deeper into tissue.
Apply a sterile, saline-moistened occlusive dressing to protect the wound.
Splint the extremity to provide immobilization, reduce pain, and prevent further soft-tissue injury.
Administer tetanus prophylaxis according to the patient’s immunization history.
Initiate hemodynamic stabilization following Advanced Trauma Life Support (ATLS) principles.

Key Clinical Pearls

Compartment Syndrome Vigilance: An open wound does not preclude the development of compartment syndrome. Maintain a high index of suspicion, as swelling can still generate dangerously high intra-compartmental pressures.
Timely Antibiotics: The first dose of appropriate intravenous antibiotics should be administered within 60 minutes of injury to be most effective.
Photo Documentation: Photograph the wound upon presentation, before cleaning and debridement. This provides an objective record to aid in classification and communication between services.

2. Imaging Modalities

Imaging is selected to define the fracture anatomy, detect radiopaque foreign bodies, and guide surgical fixation, while recognizing its limitations in assessing soft-tissue injury.

Primary and Advanced Imaging

Plain Radiography: The initial imaging of choice. Obtain at least two orthogonal views (AP and lateral) that include the entire affected bone as well as the joints above and below the fracture. Radiographs are excellent for assessing fracture pattern, comminution, and joint involvement.
Computed Tomography (CT): Indicated for polytrauma patients and for complex or periarticular fractures. CT scans with 3D reconstructions provide superior detail of the bone architecture, which is invaluable for preoperative planning.
Adjunctive Imaging: Ultrasound can be used to assess vascular flow if pulses are equivocal, but its utility is limited by dressings and operator dependence. MRI offers unparalleled detail of soft tissues, tendons, and muscles but is often impractical in the acute setting and should not delay surgical debridement.

Key Pearl: MRI Timing

Routine use of MRI in the acute phase may unnecessarily delay definitive surgical debridement. Its use should be reserved for subacute evaluation of specific soft-tissue structures when the findings would alter the management plan.

3. Laboratory Evaluation

Laboratory markers complement the clinical assessment but often lack specificity in the acute trauma setting. Serial trends are generally more informative than single values for monitoring a patient’s inflammatory response.

White Blood Cell (WBC) Count: Often elevated immediately post-trauma due to physiologic stress. A persistent or secondary upward trend may signal an evolving infection.
C-reactive Protein (CRP) & Erythrocyte Sedimentation Rate (ESR): These inflammatory markers begin to rise 6–12 hours post-injury, typically peaking at 48–72 hours. They are sensitive but highly nonspecific.
Procalcitonin: An emerging marker for differentiating bacterial infection from other inflammatory states, but its validation in the acute trauma population is still limited.

Clinical Pitfall

Do not postpone necessary operative debridement based solely on elevated inflammatory markers. The stress of severe trauma itself is the primary cause of the initial rise in WBC, CRP, and ESR. Surgical source control is the priority.

4. Gustilo-Anderson Classification System

This system stratifies open fractures based on the mechanism of injury, degree of soft-tissue damage, and level of contamination. It is a critical tool for guiding antibiotic prophylaxis, surgical timing, and predicting the risk of infection.

Gustilo-Anderson Classification for Open Fractures
Type	Definition	Infection Risk	Antibiotic Prophylaxis
I	Wound ≤1 cm, clean, simple fracture, minimal soft-tissue damage.	0–2%	Cefazolin
II	Wound >1 cm, moderate soft-tissue damage, no extensive stripping or flaps needed.	2–10%	Cefazolin
IIIA	Extensive soft-tissue laceration or damage, but adequate bone coverage is achievable.	10–25%	Cefazolin + Gentamicin
IIIB	Extensive soft-tissue loss with periosteal stripping and bone exposure; requires flap coverage.	25–50%	Cefazolin + Gentamicin (+ Penicillin for farm/soil)
IIIC	Any open fracture with an associated arterial injury that requires repair.	25–50%	As for IIIB; emergent vascular and orthoplastic consults.

Key Classification & Dosing Points

Interobserver Variability: This classification has known interobserver variability of around 60%. The definitive grade should be assigned intraoperatively after debridement.
Gram-Negative Coverage: All Type III injuries (A, B, and C) require the addition of an aminoglycoside (e.g., Gentamicin 5 mg/kg IV) for gram-negative coverage.
Anaerobic/Clostridial Coverage: For farm injuries, soil contamination, or concern for clostridial species, add Penicillin G.
Antibiotic Duration: Typically 24 hours for Types I-II. For Type III, continue for up to 72 hours or until 24 hours after definitive soft-tissue coverage is achieved, whichever comes first.

5. Diagnostic and Management Algorithm

A structured, algorithmic approach integrates clinical, imaging, and laboratory data to expedite antibiotic delivery and definitive surgical care, which are the cornerstones of preventing infection and optimizing outcomes.

Figure 1: Stepwise Management Algorithm for Open Fractures. This pathway emphasizes the critical early steps of stabilization, examination, and timely antibiotic administration, followed by a structured approach to imaging and surgical planning based on injury severity.

References

Zalavras CG. Prevention of infection in open fractures. Infect Dis Clin North Am. 2017;31(2):339–352.
EmergencyCareBC. Open Fractures – Initial Approach and Management. Published 2023.
Coombs J, et al. Current concept review: risk factors for infection following open fractures. Orthop Res Rev. 2022;14:1–11.
Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58(4):453–458.
Brumback RJ, Jones AL. Interobserver agreement in the classification of open fractures of the tibia: the Gustilo and Anderson classification system. J Bone Joint Surg Am. 1994;76(8):1162–1166.
Schottel PC, et al. Change in Gustilo-Anderson classification at time of surgery does not increase risk for surgical site infection in patients with open fractures. J Orthop Trauma. 2022;36(1):e1–e7.
Tacoma Trauma Trust. Open Fracture Management Guideline. Revised 2020.

2025 PACUPrep BCCCP Preparatory Course

Pulmonary

Participants 432

Diagnostics and Classification of Open Fractures

Diagnostics and Classification of Open Fractures

Learning Objectives

1. Clinical Presentation and Assessment

Mechanism and Inspection

Immediate Management Steps

2. Imaging Modalities

Primary and Advanced Imaging

3. Laboratory Evaluation

4. Gustilo-Anderson Classification System

5. Diagnostic and Management Algorithm

References