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2025 PACUPrep BCCCP Preparatory Course Burns Pharmacotherapy Diagnostic Assessment and Classification in Acute Burn Care

Lesson 98, Topic 2

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Diagnostic Assessment and Classification in Acute Burn Care

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Objective

Apply diagnostic and classification criteria to assess a patient with burn injury and guide initial management.

Upon completion of this chapter, the clinician will be able to:

Identify clinical signs of inhalation injury and accurately estimate Total Body Surface Area (TBSA) to prevent under‐ or over‐resuscitation.
Interpret key laboratory tests to detect hypovolemia and tissue hypoperfusion.
Use established scoring systems to stratify risk and tailor initial interventions.

1. Clinical Examination and Inhalation Injury Indicators

Early recognition of airway involvement is essential, as suspected inhalation injury significantly increases fluid requirements and mortality. The initial assessment focuses on identifying patients who need immediate airway protection.

A. Mechanism & History

The circumstances of the burn provide crucial clues about the risk of inhalation injury.

Enclosed-space fires: High risk due to concentrated smoke and toxic byproducts.
Substance involved: Fires involving plastics or chemicals can produce cyanide and other specific toxins.
Patient status: Altered mental status at the scene may be due to hypoxia, hypercarbia, or direct toxic effects.

B. Physical Examination

A thorough head-to-toe examination can reveal tell-tale signs of airway burns, though some may be subtle or delayed.

Direct signs: Singed nasal or eyebrow hairs, soot in the oropharynx or nares, and carbonaceous (sooty) sputum are classic indicators.
Functional signs: Hoarseness, stridor, or a brassy cough suggest significant laryngeal edema and impending airway obstruction.
Facial burns: Deep circumferential burns to the face and neck can cause massive edema, leading to external airway compression.

C. Bronchoscopic Assessment

Bronchoscopy is the gold standard for diagnosing and grading the severity of lower airway injury. It should be performed within the first 24 hours if any clinical signs are present.

Diagnostic findings: Direct visualization of mucosal erythema, edema, ulceration, and soot deposition confirms the diagnosis.
Prognostic value: The grade of injury (typically I-IV) correlates with the severity of lung injury and mortality risk.
Therapeutic guidance: Informs decisions on early intubation, ventilator strategies, and the need for pulmonary toilet.

Clinical Pearls

In patients with significant facial burns and hoarseness, secure the airway prophylactically before massive edema develops and makes intubation difficult or impossible.
The absence of oropharyngeal soot does not definitively rule out significant lower airway injury, especially in flash burns or steam inhalation.

2. Burn Size Estimation Techniques

Precise calculation of the Total Body Surface Area (TBSA) affected by second- and third-degree burns is the foundation of fluid resuscitation and guides decisions on triage and resource allocation.

Figure 1: Comparison of TBSA Estimation Tools. The Rule of Nines is a rapid adult assessment tool. The Lund-Browder chart is more accurate for children, reflecting their larger head-to-body ratio.

A. Rule of Nines (Adults)

This is a rapid method for estimating TBSA in adults, dividing the body into regions of 9% or multiples thereof.

Head and Neck: 9%
Each Arm: 9%
Anterior Trunk: 18%
Posterior Trunk: 18%
Each Leg: 18%
Perineum: 1%
Limitations: It is less accurate in children and obese individuals, and can lead to significant errors if not applied correctly.

B. Lund–Browder Chart (Pediatrics)

This is the preferred method for pediatric burns as it provides age-adjusted percentages for different body parts, accounting for the changing body proportions with growth. It is more accurate but also more time-consuming than the Rule of Nines.

C. Digital & Imaging Adjuncts

Modern technology offers new tools to improve accuracy, though they are not yet standard practice in all centers.

Smartphone Apps: Several applications use device cameras and augmented reality to help map burn areas and calculate TBSA.
3D Photogrammetry: Advanced scanners can create a three-dimensional model of the patient, allowing for highly precise surface area calculations. This is currently investigational.

Clinical Pearls

Only partial-thickness (second-degree) and full-thickness (third-degree) burns are included in the TBSA calculation for fluid resuscitation. Superficial (first-degree) burns are excluded.
The patient’s palm (including fingers) represents approximately 1% of their TBSA. This can be a useful tool for estimating the size of small, scattered, or patchy burns.

3. Laboratory and Perfusion Assessment

Fluid resuscitation must be guided by objective endpoints of tissue perfusion. Laboratory markers, combined with clinical signs like urine output, are essential for titrating fluid administration to avoid both under- and over-resuscitation.

Key Laboratory and Perfusion Markers in Burn Resuscitation
Parameter	Interpretation	Resuscitation Target / Goal
Urine Output	Primary indicator of renal perfusion and adequate intravascular volume.	Adults: 0.5 mL/kg/h (~30–50 mL/h) Children (<30kg): 1.0 mL/kg/h
Serum Lactate	Marker of global tissue hypoperfusion and anaerobic metabolism.	Normalize to <2 mmol/L. A downward trend indicates successful resuscitation.
Base Deficit	Reflects the severity of metabolic acidosis from shock.	Normalize to > –4 mEq/L. A worsening deficit is a critical warning sign.
Hematocrit	Indicates hemoconcentration from plasma loss into the interstitium.	Initial elevation is expected. A rapid drop may signal bleeding or over-resuscitation.
Serum Sodium	Monitors for hypernatremia, a common complication of resuscitation.	Maintain within normal limits (135-145 mEq/L).

Clinical Pearls

While lactate and base deficit are excellent adjuncts, hourly urine output remains the primary, most practical, and most widely accepted endpoint for titrating fluid resuscitation.
A rising base deficit or persistently elevated lactate during resuscitation is a red flag that demands immediate reassessment of intravascular volume, perfusion status, and potential missed injuries or developing complications like abdominal compartment syndrome.

4. Severity Scoring and Risk Stratification

Mortality prediction tools are used to standardize risk assessment, inform triage decisions, and guide discussions about prognosis. They are crucial for identifying patients who require transfer to a specialized burn center.

A. Baux Score

The Baux score is a simple yet powerful tool for predicting mortality in burn patients. The revised version incorporates the three most significant risk factors.

Figure 2: Revised Baux Score Formula. This score combines the patient’s age, the percent TBSA burned, and the presence of inhalation injury to estimate the risk of mortality. A score >140 is associated with extremely high mortality.

B. Other Systems & Integration

In clinical practice, burn-specific scores are often used alongside general trauma and critical care scoring systems, especially in patients with multiple injuries.

ABLS Algorithm: The American Burn Life Support (ABLS) course provides clear criteria for referral to a burn center, which include burn size, location (face, hands, feet, perineum), and type (chemical, electrical), as well as the presence of inhalation injury and comorbid conditions.
Polytrauma Scores: In patients with concomitant traumatic injuries, the Injury Severity Score (ISS) is calculated alongside burn scores to provide a comprehensive picture of the patient’s condition.
ICU Scores: Once admitted to the ICU, scores like APACHE II or SOFA are used for daily risk assessment and to track clinical progress.

Editor’s Note: Areas for Further Study

A comprehensive review of this topic would include a detailed breakdown of the ABLS referral criteria, validation studies comparing the original versus revised Baux score, and case examples demonstrating the integration of burn scores with general trauma scores like ISS. Furthermore, a detailed discussion of bronchoscopic inhalation injury grading scales and their specific prognostic data is warranted for advanced practice.

5. Guiding Initial Management Decisions

Accurate diagnostic assessment and classification feed directly into the critical first-hour management plan, particularly fluid resuscitation. Clear communication and documentation are vital for a successful outcome.

A. Calculated Fluid Volumes & Timing

The Parkland formula is the most widely known method for estimating initial fluid needs, though modern practice often involves a lower starting rate to mitigate the risks of “fluid creep” (resuscitation volumes exceeding predicted needs).

Parkland Formula: 4 mL of Lactated Ringer’s × patient weight (kg) × %TBSA burned.
Timing: Half of the total 24-hour volume is administered in the first 8 hours from the time of injury, and the remaining half is given over the next 16 hours.
Emerging Practice: Many centers now initiate resuscitation at a lower rate (e.g., 2-3 mL/kg/%TBSA) and titrate aggressively based on urine output and other perfusion markers to avoid over-resuscitation.

B. Interprofessional Communication & Documentation

A standardized burn flow sheet is essential for tracking resuscitation. It serves as a central communication tool for the entire care team.

Key Data Points: TBSA, inhalation injury status, chosen formula, hourly fluid rates, hourly urine output, and vital signs must be meticulously recorded.
Handoffs: The fluid resuscitation plan, including current status and next titration goals, must be a key component of every verbal handoff between nurses and physicians.

Clinical Pearls

Remember that “time zero” for the 8-hour resuscitation window is the time the injury occurred, not the time the patient arrived at the hospital. Any delay in starting fluids must be accounted for by increasing the initial infusion rate.
Early integration of a clinical pharmacist in daily burn rounds can optimize fluid and electrolyte management, helping to prevent complications like hypernatremia and ensuring appropriate use of colloids later in the resuscitation phase.

References

Nguyen TT, Gilpin DA, Meyer NA, et al. Current Treatment of Severely Burned Patients. Ann Surg. 1996;223(1):14–25.
Phillips AW, Cope O. Burn Therapy II: Respiratory Tract Damage as a Principal Killer. Ann Surg. 1962;155(1):1–10.
Herndon DN, Traber DL, Niehaus GD, et al. Pathophysiology of Smoke Inhalation Injury in a Sheep Model. J Trauma. 1984;24(12):1044–51.
Muller MJ, Herndon DN. The Challenges of Burns. Lancet. 1994;343(8894):216–20.
Cartotto R, Johnson LS, Savetamal A, et al. ABA Clinical Practice Guidelines on Burn Shock Resuscitation. J Burn Care Res. 2023;45(3):565–589.
Curry D, Smith S, Smith H, et al. Acute Adult Burn Resuscitation: Evidence‐Based Guideline. Surg Crit Care Netw. 2023;1–6.
Cochran A, Edelman LS, Saffle JR, et al. Relationship of Serum Lactate and Base Deficit to Mortality in Burns. J Burn Care Res. 2007;8(2):231–40.
Demling RH. The Burn Edema Process: Current Concepts. J Burn Care Rehabil. 2005;26(3):207–27.
Bull JP, Fisher AJ. Mortality in a Burns Unit: A Revised Estimate. Ann Surg. 1954;139(2):269–74.
Baxter CR, Shires GT. Physiologic Response to Crystalloid Resuscitation of Severe Burns. Ann N Y Acad Sci. 1968;150:874–93.

2025 PACUPrep BCCCP Preparatory Course

Pulmonary

Participants 432

Diagnostic Assessment and Classification in Acute Burn Care

Diagnostic Assessment and Classification in Acute Burn Care

Objective

1. Clinical Examination and Inhalation Injury Indicators

A. Mechanism & History

B. Physical Examination

C. Bronchoscopic Assessment

2. Burn Size Estimation Techniques

A. Rule of Nines (Adults)

B. Lund–Browder Chart (Pediatrics)

C. Digital & Imaging Adjuncts

3. Laboratory and Perfusion Assessment

4. Severity Scoring and Risk Stratification

A. Baux Score

B. Other Systems & Integration

5. Guiding Initial Management Decisions

A. Calculated Fluid Volumes & Timing

B. Interprofessional Communication & Documentation

References