1. Weaning and De-escalation Protocols

Once perfusion is restored and vasopressors are withdrawn, shifting from a positive to a neutral or negative fluid balance is critical. This “deresuscitation” phase reduces organ edema, improves organ function, and supports overall recovery.

Criteria for Initiating De-escalation

• Hemodynamic stability: Mean arterial pressure (MAP) ≥ 65 mm Hg off all vasopressors for at least 6 hours.
• Absent fluid responsiveness: A passive leg raise or fluid challenge results in a stroke volume change of less than 10%.
• Laboratory markers: Improving trends such as rising hemoglobin/hematocrit (indicating hemoconcentration), decreasing CVP, or falling natriuretic peptides.
• Imaging: Resolution of pulmonary B-lines on lung ultrasound, signifying decreased interstitial edema.

Stepwise Fluid and Vasopressor Reduction

1. Decrease maintenance or resuscitation fluids by 25–50% every 4–6 hours, guided by clinical response.
2. Taper vasopressors according to a protocolized weaning strategy, often discussed during daily multidisciplinary rounds.
3. Monitor vital signs, daily weights, strict intake/output, and renal function closely for signs of instability.

Diuretics and Ultrafiltration

• First-line therapy: Intravenous furosemide, administered as a 0.1–0.4 mg/kg bolus or a continuous infusion of 5–20 mg/h.
• Synergistic therapy: For diuretic resistance, add a thiazide-like diuretic such as metolazone 2.5–5 mg PO.
• Refractory overload: Consider slow continuous ultrafiltration (SCUF) via renal replacement therapy if diuretic strategies fail.
• Monitoring: Check electrolytes (especially potassium and magnesium), creatinine, and urine output every 6–12 hours during active deresuscitation.

2. Transition to Enteral Fluid and Electrolyte Management

Early, low-volume enteral hydration and nutrition supports gut integrity, modulates the immune response, and reduces the complications associated with prolonged reliance on parenteral fluids.

Indications & Timing

• Initiate within 24–48 hours of ICU admission, provided the patient is hemodynamically stabilizing (e.g., MAP ≥ 65 mm Hg on ≤ 0.3 µg/kg/min of norepinephrine).
• Ensure there is no evidence of ileus, lactate levels are stable or decreasing, and gut perfusion is deemed adequate.

Formulation Selection

• Standard choice: Isotonic polymeric feeds (1 kcal/mL) are suitable for most patients.
• Hyponatremia: If managing low sodium, select formulations with a higher sodium content (e.g., 100–120 mmol/L).
• Post-pyloric access: For jejunal feeding, use formulas with a low osmolality (≤ 400 mOsm/kg) to prevent osmotic diarrhea and intolerance.

Advancement & Monitoring

1. Start feeds at a trophic rate of 10–20 mL/h and advance by 10–20 mL/h every 8–12 hours as tolerated.
2. Aim to achieve at least 60% of caloric and fluid goals via the enteral route within 48–72 hours.
3. Assess for tolerance daily by checking gastric residual volumes (if used), performing an abdominal exam, and monitoring stool output.
4. Manage intolerance by reducing the feed rate or adding a prokinetic agent like metoclopramide 10 mg IV every 6 hours.

3. Prevention and Mitigation of Post-ICU Syndrome (PICS)

Post-ICU Syndrome (PICS) is a constellation of new or worsened impairments in physical, cognitive, and psychological health that persist after critical illness. A multidisciplinary bundle of care implemented during the ICU stay can significantly reduce its incidence and severity.

Risk Factors for PICS

• Fluid overload: Cumulative fluid balance exceeding 10% of admission body weight.
• Sedation: Deep or prolonged sedation (e.g., Richmond Agitation-Sedation Scale [RASS] ≤ –4).
• Immobility: More than 48 hours of bed rest or immobilization.

Mitigation Strategies (The ABCDEF Bundle)

• Early mobilization: Progress from passive range of motion to sitting, standing, and ambulating as tolerated.
• Adequate nutrition: Deliver high-protein nutrition (≥ 1.2–2.0 g/kg/day), preferably via the enteral route.
• Delirium prevention: Minimize sedation, perform daily awakening and breathing trials, and regularly assess for delirium using tools like the CAM-ICU.
• Sleep hygiene: Implement protocols to control noise and light at night to promote restorative sleep.

Psychological & Neurocognitive Support

• Encourage the use of ICU diaries and promote family engagement to orient the patient and reduce the risk of PTSD.
• Arrange for follow-up in post-ICU recovery clinics that offer ongoing physiotherapy, neuropsychology, and pharmacy support.

4. Medication Reconciliation and Discharge Counseling

A structured approach to medication reconciliation and patient education at ICU and hospital discharge is essential to minimize medication errors, prevent adverse drug events, and reduce the risk of rehospitalization.

Reconciliation Workflow

1. Aggregate and compare medication lists from three sources: pre-admission, in-hospital, and the proposed discharge regimen.
2. Explicitly resolve discrepancies for all medications, paying close attention to discontinued agents like IV fluids, diuretics, electrolytes, and vasoactive drugs.
3. Document the final, reconciled medication regimen in the electronic health record using a standardized tool (e.g., the MARQUIS model).

Patient and Caregiver Education

• Review specific fluid goals (e.g., restriction vs. liberal allowance) and any dietary sodium or potassium limits.
• Teach the patient and caregiver to recognize key signs of fluid overload (worsening leg swelling, shortness of breath) and dehydration (dizziness upon standing).
• Use the “teach-back” method to confirm understanding and provide clear, written materials for reinforcement.

Follow-up Planning

• Schedule necessary laboratory monitoring, such as serum creatinine, sodium, and potassium, for 48–72 hours post-discharge.
• Coordinate with the outpatient pharmacy and primary care provider to ensure a smooth transition and appropriate medication titration.
• Plan for pharmacist-led telephone calls or clinic visits within the first week after discharge to address any issues.