Pharmacy & Acute Care University
Pharmacy & Acute Care University
Back to Course

PACULit Literature Updates September 2025: Emergency Medicine & Critical Care

0% Complete
0/0 Steps
  1. Use of a drug-related problem oriented medical record in the medication review of critically ill patients Randomized clinical trial
    1 Topic
    |
    1 Quiz
  2. PACULit Daily Literature Update: Stress hyperglycemia ratio as a biomarker for early mortality risk stratification in cardiovascular disease a propensity matched analysis
    1 Topic
    |
    1 Quiz
  3. PACULit Daily Literature Update: Initial serum electrolyte imbalances and mortality in patients with traumatic brain injury a retrospective study
    1 Topic
    |
    1 Quiz
  4. PACULit Daily Literature Update: AsNeeded AlbuterolBudesonide in Mild Asthma
    1 Topic
    |
    1 Quiz
  5. PACULit Daily Literature Update: Thiamine as a metabolic resuscitator after in hospital cardiac arrest
    1 Topic
    |
    1 Quiz
  6. PACULit Daily Literature Update: The Effect of Early Fluid Resuscitation on Mortality in Sepsis A Systematic Review and Meta Analysis
    1 Topic
    |
    1 Quiz
  7. PACULit Daily Literature Update: Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial
    1 Topic
    |
    1 Quiz
  8. PACULit Daily Literature Update: Prevalence risk factors and consequences of early clinical deterioration under noninvasive ventilation in emergency department patients a prospective multicentre observational study of the French IRU Network
    1 Topic
    |
    1 Quiz
  9. PACULit Daily Literature Update: Evaluation of Stress Dose Hydrocortisone Tapers in Septic Shock
    1 Topic
    |
    1 Quiz
  10. Opportunistic Screening for Atrial Fibrillation With Continuous ECG Monitoring in the Emergency Department
    1 Topic
    |
    1 Quiz
  11. PACULit Daily Literature Update: Efficacy of targeting high mean arterial pressure for older patients with septic shock OPTPRESS a multicentre pragmatic open label randomised controlled trial
    1 Quiz
  12. PACULit Daily Literature Update: Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients
    1 Topic
    |
    1 Quiz
  13. PACULit Daily Literature Update: Andexanet alfa increases 30-day thrombotic events relative to four-factor prothrombin complex concentrate for factor Xa inhibitors related intracerebral hemorrhage in veterans
    1 Topic
    |
    1 Quiz
  14. PACULit Daily Literature Update: Antibiotic De-Escalation Practices in the Intensive Care Unit A Multicenter Observational Study
    1 Topic
    |
    1 Quiz
  15. PACULit Daily Literature Update: Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage Protocol for an international phase 3 randomised placebocontrolled multicentre trial
    1 Topic
    |
    1 Quiz
  16. PACULit Daily Literature Update: Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest
    1 Topic
    |
    1 Quiz
  17. PACULit Daily Literature Update: Real-Time Hemodynamic Responses to Epinephrine and Their Association with ROSC in Out-of-Hospital Cardiac Arrest
    1 Topic
    |
    1 Quiz
  18. Reevaluating bicarbonate therapy in pediatric DKA A propensity scorematched analysis of neurological and respiratory outcomes
    1 Topic
    |
    1 Quiz
  19. PACULit Daily Literature Update: Establishing discordance rate of estimated glomerular filtration rate between serum creatinine based calculations and cystatin C based calculations in critically ill patients
    1 Topic
    |
    1 Quiz
  20. Alteplase for Posterior Circulation Ischemic Stroke at 45 to 24 Hours
    1 Topic
    |
    1 Quiz
  21. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
    1 Topic
    |
    2 Quizzes
  22. ACPE Required Forms: PACULit Literature Updates September 2025: Emergency Medicine & Critical Care
    3 Topics

Quizzes

Participants 440

  • Allison Clemens
  • April
  • ababaabhay
  • achoi2392
  • adhoward1
Show more
Lesson Progress
0% Complete
PACULit Logo

Daily Literature Update

2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

Jones DW, et al. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2025 Aug 8:S0735-1097(25)06480-0. doi: 10.1016/j.jacc.2025.05.007. Epub ahead of print. PMID: 40815242.

Introduction

Hypertension is a leading cause of cardiovascular disease globally necessitating evidence-based management strategies.

Guideline Development: Joint expert committee report

Key Evidence Base: Landmark randomized controlled trials focused on intensive BP control

Population: Adults at elevated cardiovascular risk without diabetes or prior stroke

Recommendations: Intensive systolic BP target <120 mm Hg to reduce cardiovascular events

Key Findings

  • SPRINT trial showed reduced major CV events and mortality with intensive BP control (Wright et al., 2015)
  • Long-term SPRINT follow-up confirmed benefits and quantified risks such as hypotension, acute kidney injury (Lewis et al., 2021)
  • Guideline recommendations directly informed by this high-quality evidence base
  • Evidence gaps remain for excluded populations like diabetes and stroke patients

Context & Related Research

  • Jones DW et al., 2025: Comprehensive guideline integrating evidence to optimize BP control with intensive targets (PMID:40815242)
  • Wright JT Jr et al., 2015: Landmark RCT showing cardiovascular and mortality benefit from SBP <120 mm Hg (PMID:26551272)
  • Lewis CE et al., 2021: Final SPRINT report detailing sustained benefits and adverse event risks with intensive BP lowering (PMID:34010531)

Clinical Implications

  • Consider intensive BP control (<120 mm Hg) in selected high-risk adults without diabetes or stroke
  • Monitor closely for hypotension and kidney function changes during intensive management
  • Individualize therapy balancing cardiovascular benefits and adverse event risks

Strengths & Limitations

Strengths Limitations
High-quality evidence synthesis from landmark trials Excludes important patient groups such as those with diabetes or stroke
Joint multi-society guideline development Real-world implementation challenges for intensive targets
Clear risk-benefit framework to guide clinical care Long-term renal safety remains uncertain

Future Directions

Additional research needed on intensive BP control in excluded populations, long-term renal outcomes, and practical implementation strategies.

Conclusion

The 2025 AHA/ACC guideline endorses intensive blood pressure control grounded in robust evidence, balancing cardiovascular benefits with safety considerations.

Listen to the Podcast

A short discussion of today’s highlight.

Open the episode in a new tab

© 2025 PACULit