Statins for STEMI in the Emergency Department
Introduction Pharmacology Atorvastatin Rosuvastatin Dose 80 mg orally once daily 40 mg orally once daily Administration Oral Oral PK/PD Onset: 3-5 days for LDL…
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Corticosteroids in Sepsis by Marissa Marks, PharmD
Introduction Pharmacology Hydrocortisone Methylprednisolone Fludrocortisone Dose IV: 50 mg Q6H or 100 mg Q8H x 5-7 days IV (succinate): 40 to 125 mg/day (maximum…
Alteplase for Acute Ischemic Stroke
Introduction Alteplase (rt-PA) has been used for acute ischemic stroke since its approval by the FDA in 1996 after publication of promising results of…
Hypertonic Saline Versus Mannitol for ICP Reduction
Introduction Elevated intracranial pressure (ICP) is caused by excess volume in the cerebral spaces, which causes a reduction in the cerebral perfusion pressure and…
Management of Hypertensive Emergency
Introduction Hypertensive emergency is characterized by systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 120 mmHg with evidence of target…