Post-Quiz: Parkinson’s Disease

Which of the following is the most appropriate pharmacotherapy for the patient’s Parkinson disease?

A 65-year-old male presents to the clinic with a 2-year history of tremors in his right hand. He also reports stiffness and slowness of movement. On examination, he has a resting tremor in his right hand, cogwheel rigidity, and bradykinesia. His Montreal Cognitive Assessment (MoCA) score is 25/30. MRI of the brain shows no abnormalities. The patient is diagnosed with Parkinson disease. Which of the following adverse effects should be monitored when initiating and monitoring pharmacotherapy for Parkinson disease?

A 72-year-old female patient presents with a 6-month history of progressive tremor in her right hand, rigidity, and bradykinesia. She has a family history of Parkinson’s disease, and her father was diagnosed at the age of 65. She reports difficulty with daily activities, such as buttoning her shirt and using utensils. Physical examination reveals cogwheel rigidity and a shuffling gait. Based on the patient’s history and presentation, what is the most likely diagnosis, and what is the most appropriate initial pharmacotherapy?

A 65-year-old male patient presents to the clinic with tremors and stiffness in his limbs that have been progressively worsening over the last year. After performing an evaluation, the patient was diagnosed with Parkinson disease. The physician prescribes drug therapy to manage the patient’s symptoms. Which medication should be the first-line treatment for this patient?

K.M. is a 65-year-old man presenting to the neurology clinic with a 6-month history of progressive tremors in his right hand, stiffness in his right arm, and difficulty in walking. His medical history includes hypertension and type 2 diabetes mellitus. He has been taking metformin 500 mg twice daily and amlodipine 5 mg once daily. He has no family history of neurodegenerative diseases. On examination, the patient exhibits a resting tremor in his right hand, cogwheel rigidity in his right arm, and bradykinesia. Based on K.M.’s clinical presentation and medical history, what is the most probable diagnosis, and which of the following medications is most appropriate as the initial treatment?