Mr. Johnson is a 72-year-old male admitted to the ICU with septic shock secondary to pneumonia. His medical history includes chronic hypertension and stage 3 chronic kidney disease. He is currently receiving norepinephrine infusion to maintain blood pressure. The ICU team is considering targeting a higher mean arterial pressure (MAP) of 80-85 mmHg to potentially protect renal function.

Based on the OPTPRESS trial findings, what is the most appropriate MAP target for Mr. Johnson to optimize outcomes?

Mrs. Lee is a 68-year-old female with septic shock and a history of chronic hypertension. She is on vasopressor therapy with norepinephrine. The critical care team asks the pharmacist about the potential benefits of targeting a higher MAP to prevent renal replacement therapy.

What advice should the pharmacist provide regarding MAP targets in this patient based on current evidence including the OPTPRESS trial?

Mr. Smith is a 75-year-old patient with septic shock requiring norepinephrine infusion. The ICU team plans to titrate vasopressors to maintain a MAP of 80 mmHg. The pharmacist is asked to review this plan and provide recommendations.

What is the most appropriate pharmacist recommendation regarding vasopressor titration and MAP targets in this patient?