Literature Review Quiz: Hypertensive Urgency and Emergency Management

According to the 2017 ACC/AHA Hypertension guideline, what is the definition of a hypertensive emergency?

a. A severe elevation of BP (>180/120 mm Hg) with evidence of new or worsening target organ damage
b. A severe elevation of BP (>160/100 mm Hg) with evidence of impending or progressive target organ damage
c. A moderate elevation of BP (>140/90 mm Hg) with evidence of acute or chronic target organ damage
d. A moderate elevation of BP (>130/80 mm Hg) with evidence of potential or reversible target organ damage

In the 2017 ACC/AHA Hypertension guideline, what is the recommended initial goal for BP reduction in patients with a hypertensive emergency?

What is the primary objective of the INTERACT3 trial?

What was the primary outcome of the INTERACT3 trial?

According to the CLUE trial, what was the primary outcome and how was it defined?

a. The change in systolic blood pressure (SBP) from baseline to 30 minutes after the initiation of treatment, defined as the difference between the SBP at 30 minutes and the SBP at baseline
b. The achievement of target blood pressure (BP) range within 30 minutes of the initiation of treatment, defined as a SBP between 140 and 160 mm Hg and a diastolic BP (DBP) between 90 and 100 mm Hg
c. The incidence of adverse events within 24 hours of the initiation of treatment, defined as any undesirable clinical or laboratory changes that occurred or worsened during or after the treatment
d. The length of stay in the emergency department (ED), defined as the time from ED arrival to ED discharge or admission

In the CLUE trial, what were the inclusion and exclusion criteria for the patients?

a. Inclusion criteria: age ≥18 years, SBP ≥180 mm Hg or DBP ≥110 mm Hg, diagnosis of hypertensive emergency; exclusion criteria: pregnancy, allergy or contraindication to study drugs, use of IV antihypertensive agents within 6 hours, need for immediate surgery or endovascular intervention
b. Inclusion criteria: age ≥18 years, SBP ≥160 mm Hg or DBP ≥100 mm Hg, diagnosis of hypertensive urgency; exclusion criteria: pregnancy, allergy or contraindication to study drugs, use of IV antihypertensive agents within 6 hours, need for immediate surgery or endovascular intervention
c. Inclusion criteria: age ≥18 years, SBP ≥180 mm Hg or DBP ≥110 mm Hg, diagnosis of hypertensive urgency; exclusion criteria: pregnancy, allergy or contraindication to study drugs, use of IV antihypertensive agents within 6 hours, need for immediate surgery or endovascular intervention
d. Inclusion criteria: age ≥18 years, SBP ≥160 mm Hg or DBP ≥100 mm Hg, diagnosis of hypertensive emergency; exclusion criteria: pregnancy, allergy or contraindication to study drugs, use of IV antihypertensive agents within 6 hours, need for immediate surgery or endovascular intervention

Cardiology 101