10.1 Salicylate Toxicity Assessment Quiz – Pharmacy & Acute Care University

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Salicylate Toxicity for Pharmacists 10.1 Salicylate Toxicity Assessment Quiz

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Question 1 of 12

1. Question
1. Which of the following is most consistent with chronic salicylate toxicity?
- A. Tachypnea and respiratory alkalosis
- B. Metabolic acidosis with normal anion gap
- C. Altered mental status and seizures
- D. Tinnitus and gastrointestinal bleeding
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Question 2 of 12

2. Question
1. A 62-year-old woman has nausea, vomiting and confusion. Her serum salicylate level is 19 mg/dL. She most likely has:
- A. Acute salicylate toxicity
- B. Chronic salicylate toxicity
- C. Side effects from appropriate dosing
- D. Laboratory error causing a false reading
Correct

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Question 3 of 12

3. Question
1. Salicylates interfere with aerobic cellular respiration primarily by:
- A. Inhibiting the citric acid cycle
- B. Uncoupling oxidative phosphorylation
- C. Increasing free fatty acid production
- D. Directly stimulating the respiratory center
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Question 4 of 12

4. Question
1. Which of the following is the most severe complication of salicylate’s effect on glucose metabolism?
- A. Hyperglycemia
- B. Hypokalemia
- C. Ketoacidosis
- D. Cerebral hypoglycemia
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Question 5 of 12

5. Question
1. A 25-year-old man presents with altered mental status after aspirin overdose. His salicylate level is 42 mg/dL and serum pH is 7.3. This indicates:
- A. His toxicity is not severe based on the level
- B. Hepatic metabolism is enhancing elimination
- C. Salicylate is redistributing into the CNS
- D. The elevated pH prevents CNS effects
Correct

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Question 6 of 12

6. Question
1. Which of the following can result in falsely normal anion gap in significant salicylate toxicity?
- A. Renal tubular acidosis
- B. Concurrent iron overdose
- C. Laboratory assay interference
- D. Medication-induced pancreatitis
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Question 7 of 12

7. Question
1. Which of the following medications reverses neuroglycopenia in salicylate poisoning?
- A. Acetylcysteine
- B. Activated charcoal
- C. Sodium bicarbonate
- D. Intravenous dextrose
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Question 8 of 12

8. Question
1. A patient with a salicylate level of 70 mg/dL and severe pulmonary edema requires intubation. To prevent precipitous decline, the provider should:
- A. Use ketamine for sedation
- B. Give sodium bicarbonate before intubation
- C. Intubate only if respiratory acidosis develops
- D. Match pre-intubation minute ventilation
Correct

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Question 9 of 12

9. Question
1. Which of the following is the major limitation in using high-dose sodium bicarbonate to manage salicylate toxicity?
- A. Paradoxical intracellular acidosis
- B. Precipitation of metabolic alkalosis
- C. Induction of hypokalemia
- D. Worsening of pulmonary edema
Correct

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Question 10 of 12

10. Question
1. How does activated charcoal administration aid in managing salicylate toxicity?
- A. Absorbs salicylate in the gastrointestinal tract
- B. Buffers metabolic acidosis
- C. Provides glucose substrate for the CNS
- D. Binds iron to prevent further toxicity
Correct

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Question 11 of 12

11. Question
1. An 81-year-old man presents with chronic salicylate toxicity and a level of 45 mg/dL. His creatinine is 1.6 mg/dL at baseline. When should hemodialysis be initiated?
- A. Salicylate level greater than 60 mg/dL
- B. Creatinine increase by 0.5 mg/dL
- C. Progressive symptoms despite treatment
- D. Salicylate level greater than 40 mg/dL
Correct

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Question 12 of 12

12. Question
1. Which of the following medications can cause falsely elevated salicylate levels on laboratory assay?
- A. Ascorbic acid
- B. Acetaminophen
- C. Furosemide
- D. Promethazine
Correct

Incorrect

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