Epinephrine has been recommended by guidelines since 1974, with literature supporting it’s use dating back to 1906.
There is controversy as to whether epinpehrine is the preferred vasopressor in cardiac arrest due to potential increase in myocardial demand, cerebral vasoconstrictor, and lack of long term data supporting it’s use.
Vasopressin is an alternative to epinephrine that has inconsistent data to support it as a superior vasopressor agent in cardiac arrest.
Combination therapy with vasopressin, steroids, and epinephrine is a promising drug regimen in cardiac arres the will need further studies to validate it’s use as a standard therapy in patients experiencing cardiac arrest.
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