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PACULit Literature Updates September 2025: Emergency Medicine & Critical Care

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  1. Use of a drug-related problem oriented medical record in the medication review of critically ill patients Randomized clinical trial
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    1 Quiz
  2. PACULit Daily Literature Update: Stress hyperglycemia ratio as a biomarker for early mortality risk stratification in cardiovascular disease a propensity matched analysis
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    1 Quiz
  3. PACULit Daily Literature Update: Initial serum electrolyte imbalances and mortality in patients with traumatic brain injury a retrospective study
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    1 Quiz
  4. PACULit Daily Literature Update: AsNeeded AlbuterolBudesonide in Mild Asthma
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    1 Quiz
  5. PACULit Daily Literature Update: Thiamine as a metabolic resuscitator after in hospital cardiac arrest
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    1 Quiz
  6. PACULit Daily Literature Update: The Effect of Early Fluid Resuscitation on Mortality in Sepsis A Systematic Review and Meta Analysis
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    1 Quiz
  7. PACULit Daily Literature Update: Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial
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    1 Quiz
  8. PACULit Daily Literature Update: Prevalence risk factors and consequences of early clinical deterioration under noninvasive ventilation in emergency department patients a prospective multicentre observational study of the French IRU Network
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    1 Quiz
  9. PACULit Daily Literature Update: Evaluation of Stress Dose Hydrocortisone Tapers in Septic Shock
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    1 Quiz
  10. Opportunistic Screening for Atrial Fibrillation With Continuous ECG Monitoring in the Emergency Department
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    1 Quiz
  11. PACULit Daily Literature Update: Efficacy of targeting high mean arterial pressure for older patients with septic shock OPTPRESS a multicentre pragmatic open label randomised controlled trial
    1 Quiz
  12. PACULit Daily Literature Update: Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients
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    1 Quiz
  13. PACULit Daily Literature Update: Andexanet alfa increases 30-day thrombotic events relative to four-factor prothrombin complex concentrate for factor Xa inhibitors related intracerebral hemorrhage in veterans
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    1 Quiz
  14. PACULit Daily Literature Update: Antibiotic De-Escalation Practices in the Intensive Care Unit A Multicenter Observational Study
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    1 Quiz
  15. PACULit Daily Literature Update: Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage Protocol for an international phase 3 randomised placebocontrolled multicentre trial
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    1 Quiz
  16. PACULit Daily Literature Update: Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest
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    1 Quiz
  17. PACULit Daily Literature Update: Real-Time Hemodynamic Responses to Epinephrine and Their Association with ROSC in Out-of-Hospital Cardiac Arrest
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    1 Quiz
  18. Reevaluating bicarbonate therapy in pediatric DKA A propensity scorematched analysis of neurological and respiratory outcomes
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    1 Quiz
    1. Reevaluating bicarbonate therapy in pediatric DKA A propensity scorematched analysis of neurological and respiratory outcomes
  19. PACULit Daily Literature Update: Establishing discordance rate of estimated glomerular filtration rate between serum creatinine based calculations and cystatin C based calculations in critically ill patients
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  20. Alteplase for Posterior Circulation Ischemic Stroke at 45 to 24 Hours
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  21. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
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    2 Quizzes
  22. ACPE Required Forms: PACULit Literature Updates September 2025: Emergency Medicine & Critical Care
    3 Topics

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PACULit Literature Updates September 2025: Emergency Medicine & Critical Care Reevaluating bicarbonate therapy in pediatric DKA A propensity scorematched analysis of neurological and respiratory outcomes
Lesson 18 of 22
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Reevaluating bicarbonate therapy in pediatric DKA A propensity scorematched analysis of neurological and respiratory outcomes

Reevaluating bicarbonate therapy in pediatric DKA A propensity score-matched analysis of neurological and respiratory outcomes

Patel M, Afifi AM, Hercher RL, et al. Reevaluating bicarbonate therapy in pediatric DKA: A propensity score-matched analysis of neurological and respiratory outcomes. Am J Emerg Med. 2025 Jul;97:45-50. doi: 10.1016/j.ajem.2025.07.033. PMID: 40683034 | PMID: 40683034

Study Type

Propensity Score-Matched Analysis

Population

Pediatric patients with diabetic ketoacidosis (DKA)

Intervention

Bicarbonate therapy versus no bicarbonate therapy

Follow-up

During hospital stay (short term)

This study evaluated the neurological and respiratory outcomes associated with bicarbonate therapy in pediatric patients with diabetic ketoacidosis using propensity score-matched analysis to control for confounding variables.

Key Learning Points

  • •
    Bicarbonate therapy in pediatric DKA was not associated with improved neurological or respiratory outcomes in this matched cohort.
  • •
    Clinicians should reconsider routine bicarbonate use in pediatric DKA given the lack of demonstrated benefit and potential risks.


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