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PACULit Literature Updates September 2025: Oncology

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  1. Immune mediated adverse events in the randomized phase 3 TOPAZ 1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer
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    1 Quiz
  2. Belantamab mafodotin plus bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma DREAMM7 updated overall survival analysis from a global randomised open label phase 3 trial
    1 Topic
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    1 Quiz
  3. PACULit Daily Literature Update: Real-world patient profile and step-up dosing process of early initiators of teclistamab for multiple myeloma in US hospitals An analysis using the Premier Healthcare Database
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    1 Quiz
  4. PACULit Daily Literature Update: Effects of BojungikkiTang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors a randomized pilot study
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    1 Quiz
  5. PACULit Daily Literature Update: Long acting lipegfilgrastim and antimicrobials as vigorous primary prophylaxis in bendamustine treated patients with indolent B cell non Hodgkin lymphoma a multicentric real life experience
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    1 Quiz
  6. First-line treatment with HDACis plus tislelizumab combined with chemotherapy in advanced NSCLC a single-arm phase II study
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  7. Comparison of outcomes with elranatamab and real world treatments in the UK for triple class exposed relapsed and refractory multiple myeloma
    1 Topic
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    1 Quiz
  8. Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer
    1 Topic
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    1 Quiz
  9. Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure
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    1 Quiz
  10. Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design
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    1. Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design
  11. Brentuximab vedotin plus chemotherapy for the treatment of frontline systemic anaplastic large cell lymphoma subgroup analysis of the ECHELON2 study at 5 years followup
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  12. Effectiveness and Safety of Immunotherapy for Hepatocellular Carcinoma in Clinical Practice A Brazilian Multicenter Study
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    1 Quiz
  13. Talquetamab improves patient reported symptoms and health related quality of life in relapsed or refractory multiple myeloma Results from the phase 12 MonumenTAL1 study
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    1 Quiz
  14. Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer
    1 Topic
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    1 Quiz
  15. Durvalumab Alone or Combined With Novel Agents for Unresectable Stage III Non Small Cell Lung Cancer Update From the COAST Randomized Clinical Trial
    1 Topic
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    1 Quiz
  16. Real world patient profile and step up dosing process of early initiators of teclistamab for multiple myeloma in US hospitals An analysis using the Premier Healthcare Database
    1 Topic
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    1 Quiz
  17. Virtual reality for outpatient management of cancer pain a pilot dosing study
    1 Topic
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    1 Quiz
  18. Brentuximab vedotin plus chemotherapy for the treatment of frontline systemic anaplastic large cell lymphoma
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    1 Quiz
  19. Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors should we treat beyond two years
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    1 Quiz
  20. Effects of Metformin on Survival and Toxicity in Patients with Metastatic Non Small Cell Lung Cancer Treated with Nivolumab
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    1 Quiz
  21. ACPE Required Forms: PACULit Literature Updates September 2025: Oncology
    3 Topics

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PACULit Literature Updates September 2025: Oncology Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design
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Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design

Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design

Montagna D, Comoli P, Tanzi M, et al. Phase I/II clinical trial on the safety and preliminary efficacy of donor-derived anti-leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation: study rational and design. Front Immunol. 2025 ;16:1601961-. doi: 1601961. | PMID: 40547030

Study Type

Phase I/II Clinical Trial

Population

Children undergoing haploidentical hematopoietic stem cell transplantation

Intervention

Donor-derived anti-leukemia cytotoxic T lymphocytes

Follow-up

Preliminary follow-up as per trial design

This Phase I/II clinical trial evaluates the safety and preliminary efficacy of donor-derived anti-leukemia cytotoxic T lymphocytes administered to children undergoing haploidentical hematopoietic stem cell transplantation, aiming to prevent leukemia relapse.

Key Learning Points

  • •
    Donor-derived anti-leukemia cytotoxic T lymphocytes show promise for reducing relapse risk in pediatric patients after haploidentical stem cell transplant.
  • •
    The trial design assesses both safety and preliminary efficacy to inform future larger studies.


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