PACULit Daily Literature Update: Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage Protocol for an international phase 3 randomised placebocontrolled multicentre trial

Cohen J, Delaney A, Udy A, et al. Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial. Crit Care Resusc. 2025 Jun;27(2):100116-. doi: 100116. | PMID: 40677678

Protocol description for an international, phase 3 randomised placebo-controlled multicentre trial investigating the efficacy and safety of fludrocortisone to treat patients suffering from aneurysmal subarachnoid haemorrhage.

Key Learning Points

• •
  Fludrocortisone is being evaluated as a potential treatment to improve outcomes in patients with aneurysmal subarachnoid haemorrhage.
• •
  This international multicentre trial will provide high-quality evidence on the efficacy and safety of fludrocortisone in this patient population.