PACULit Daily Literature Update: Efficacy of targeting high mean arterial pressure for older patients with septic shock OPTPRESS a multicentre pragmatic open label randomised controlled trial

Endo A, Yamakawa K, Tagami T, et al. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med. 2025 May;51(5):883-892. doi: 10.1007/s00134-025-07910-4. PMID: 40358717 | PMID: 40358717

This study evaluated whether targeting a higher mean arterial pressure during resuscitation improves outcomes in older septic shock patients, using a multicentre, pragmatic, open-label randomized controlled trial design.

Key Learning Points

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  Targeting higher mean arterial pressure did not significantly reduce mortality in older patients with septic shock.
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  The intervention was safe and well tolerated, guiding individualized blood pressure targets may be beneficial.