PACULit Literature Updates September 2025: Oncology
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Immune mediated adverse events in the randomized phase 3 TOPAZ 1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer1 Topic|1 Quiz
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Belantamab mafodotin plus bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma DREAMM7 updated overall survival analysis from a global randomised open label phase 3 trial1 Topic|1 Quiz
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PACULit Daily Literature Update: Real-world patient profile and step-up dosing process of early initiators of teclistamab for multiple myeloma in US hospitals An analysis using the Premier Healthcare Database1 Topic|1 Quiz
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PACULit Daily Literature Update: Effects of BojungikkiTang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors a randomized pilot study1 Topic|1 Quiz
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PACULit Daily Literature Update: Long acting lipegfilgrastim and antimicrobials as vigorous primary prophylaxis in bendamustine treated patients with indolent B cell non Hodgkin lymphoma a multicentric real life experience1 Topic|1 Quiz
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First-line treatment with HDACis plus tislelizumab combined with chemotherapy in advanced NSCLC a single-arm phase II study1 Topic|1 Quiz
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Comparison of outcomes with elranatamab and real world treatments in the UK for triple class exposed relapsed and refractory multiple myeloma1 Topic|1 Quiz
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Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer1 Topic|1 Quiz
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Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure1 Topic|1 Quiz
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Phase I II clinical trial on the safety and preliminary efficacy of donor derived anti leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation study rational and design1 Topic|1 Quiz
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Brentuximab vedotin plus chemotherapy for the treatment of frontline systemic anaplastic large cell lymphoma subgroup analysis of the ECHELON2 study at 5 years followup1 Topic|1 Quiz
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Effectiveness and Safety of Immunotherapy for Hepatocellular Carcinoma in Clinical Practice A Brazilian Multicenter Study1 Topic|1 Quiz
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Talquetamab improves patient reported symptoms and health related quality of life in relapsed or refractory multiple myeloma Results from the phase 12 MonumenTAL1 study1 Topic|1 Quiz
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Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer1 Topic|1 Quiz
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Durvalumab Alone or Combined With Novel Agents for Unresectable Stage III Non Small Cell Lung Cancer Update From the COAST Randomized Clinical Trial1 Topic|1 Quiz
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Real world patient profile and step up dosing process of early initiators of teclistamab for multiple myeloma in US hospitals An analysis using the Premier Healthcare Database1 Topic|1 Quiz
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Virtual reality for outpatient management of cancer pain a pilot dosing study1 Topic|1 Quiz
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Brentuximab vedotin plus chemotherapy for the treatment of frontline systemic anaplastic large cell lymphoma1 Topic|1 Quiz
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Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors should we treat beyond two years1 Topic|1 Quiz
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Effects of Metformin on Survival and Toxicity in Patients with Metastatic Non Small Cell Lung Cancer Treated with Nivolumab1 Topic|1 Quiz
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ACPE Required Forms: PACULit Literature Updates September 2025: Oncology3 Topics
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Virtual reality for outpatient management of cancer pain a pilot dosing study Quiz
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Question 1 of 3
1. Question
James is a 58-year-old African American male with metastatic lung cancer experiencing chronic cancer-related pain rated 6/10. He is currently on a stable opioid regimen including oxycodone 20 mg every 8 hours as needed for breakthrough pain. He reports dissatisfaction with his current pain control and is interested in nonpharmacological options. He has no history of seizures or motion sickness and has access to a Meta Quest 2 VR headset provided by his oncology clinic.
Question: Based on the pilot dosing study by Groninger et al., what VR dosing schedule should the pharmacist recommend to optimize analgesic benefits for James’ chronic cancer pain?
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Question 2 of 3
2. Question
Linda is a 62-year-old woman with breast cancer and chronic pain managed with morphine extended-release 30 mg twice daily and hydromorphone 2 mg as needed for breakthrough pain. She has started using VR distraction therapy daily for 10 minutes as part of her outpatient pain management. She asks whether VR will help reduce her need for breakthrough opioids.
Question: What should the pharmacist counsel Linda regarding the effect of VR therapy on breakthrough opioid use based on current evidence?
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Question 3 of 3
3. Question
Maria is a 54-year-old African American female with chronic cancer pain who has been prescribed VR therapy using a Meta Quest 2 headset. She is concerned about potential side effects and how to integrate VR into her daily routine alongside her current medications, including gabapentin 300 mg three times daily and fentanyl patch 50 mcg/hr.
Question: What key counseling points should the pharmacist provide to Maria about VR therapy based on the pilot study findings?
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