PACUlit Clinical Trials Dashboard
| Title | Disease States | Specialty | Summary Link |
|---|---|---|---|
| Nielsen N, et al. “Target Temperature Management 33°C vs. 36°C after Out-of Hospital Cardiac Arrest”. The New England Journal of Medicine. 2013. 369(23):2197-2206. | Cardiac Arrest |
Critical Care Medicine
|
Summary Link |
| Topol E, et al. “An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction”. The New England Journal of Medicine. 1993. 329(10):673-682. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Cohen M, et al. “A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease”. The New England Journal of Medicine. 1997. 337(7):447-452. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Hochman J.S., et al. “Coronary Intervention for Persistent Occlusion after Myocardial Infarction”. The New England Journal of Medicine. 2006. 355(23):2395-2407. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| McFalls EO, et al. “Coronary-artery revascularization before elective major vascular surgery”. The New England Journal of Medicine. 2004. 351(27):2795-2804. | Coronary Artery Disease |
Cardiology
|
Summary Link |
| Holzer M, et al. “Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest”. The New England Journal of Medicine. 2002. 346(8):549-556. | Cardiac Arrest |
Critical Care Medicine
|
Summary Link |
| Marso SP, et al. “Liraglutide and cardiovascular outcomes in type 2 diabetes”. The New England Journal of Medicine. 2016. 375(4):311-322. | Diabetes Mellitus |
Cardiology
|
Summary Link |
| ARISE Trial. “Goal-directed resuscitation for patients with early septic shock”. The New England Journal of Medicine. 2014. 371(16):1496-1506. | Sepsis |
Critical Care
|
Summary Link |
| Lamontagne, F, et al. “Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit”. New England Journal of Medicine. 2022. 386(25):2387-2398. | Sepsis |
Critical Care
|
Summary Link |
| Fujii T, et al. “Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: The VITAMINS randomized clinical trial”. JAMA. 2020. 323(5):423-431. | Sepsis |
Critical Care
|
Summary Link |
| The implementation of an analgesia-based sedation protocol reduced deep sedation and proved to be safe and feasible in patients on mechanical ventilation. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| Non-steroidal anti-inflammatory drugs in treatment of postoperative pain after cardiac surgery. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| PROCESS trial: Protocol-based therapy for septic shock | Sepsis |
Critical Care Medicine
|
Summary Link |
| Psychiatric outcomes of patients with severe agitation following administration of prehospital ketamine. | Acute Agitation |
Emergency Medicine
|
Summary Link |
| Gibson CM, et al. “Prevention of bleeding in patients with AF undergoing PCI”. The New England Journal of Medicine. 2016. epub 2016-11-14:1-12. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Moss AJ, et al. “Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction”. The New England Journal of Medicine. 2002. 346(12):877-883. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Swedberg K, et al. “Treatment of anemia with darbepoetin alfa in systolic heart failure”. The New England Journal of Medicine. 2013. 368(13):1210-9. | Heart Failure |
Cardiology
|
Summary Link |
| Manson JE, et al. “Vitamin D supplements and prevention of cancer and cardiovascular disease”. The New England Journal of Medicine. 2019. 380(1):33-44. | Oncology Supportive Care |
Oncology
|
Summary Link |
| Pitt B, et al. “Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction”. The New England Journal of Medicine. 2003. 348(14):1309-21. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Bonaca MP, et al. “Long-term use of ticagrelor in patients with prior myocardial infarction”. The New England Journal of Medicine. 2015. 372(19):1791-1800. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. | Acute Agitation |
Emergency Medicine
|
Summary Link |
| Echt DS, et al. “Mortality and morbidity in patients receiving encainide, flecainide, or placebo”. The New England Journal of Medicine. 1991. 324(12):781-788. | Ventricular Arrythima |
Cardiology
|
Summary Link |
| Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Angiography”. Circulation. 2011. 124:1250-1259 | Acute Kidney Injury |
Nephrology
|
Summary Link |
| Bandstein N, et al. “Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction”. Journal of the American College of Cardiology. 2014. 63(23):2569-2578. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: A prospective, randomized study. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| Intermittent Versus Continuous Infusion Dosing of Intravenous Proton Pump Inhibitors | Peptic Ulcer Disease |
Gastroenterology
|
Summary Link |
| Dankiewicz J, et al. “Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest”. The New England Journal of Medicine. 2021. 384(24):2283-2294. | Cardiac Arrest |
Critical Care Medicine
|
Summary Link |
| Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. | Acute Agitation |
Emergency Medicine
|
Summary Link |
| Yusuf S, et al. “Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation”. The New England Journal of Medicine. 2001. 345(7):494-502. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Tardif J, et al. “Efficacy and safety of low-dose colchicine after myocardial infarction”. The New England Journal of Medicine. 2019. 381(26):2497-2505. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| NINDS: TISSUE PLASMINOGEN ACTIVATOR FOR ACUTE ISCHEMIC STROKE | N/A |
Neurology
|
Summary Link |
| Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: A randomized, double-blind placebo controlled trial. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison. | Analgesia, and Delirium, Post-Intubation Sedation |
Critical Care Medicine
|
Summary Link |
| Yusuf S, et al. “Comparison of fondaparinux and enoxaparin in acute coronary syndromes”. The New England Journal of Medicine. 2006. 354(14):1464-1476. | N/A |
Cardiology
|
Summary Link |
| Dose comparisons of clopidogrel and aspirin in acute coronary syndromes | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Hoberman A, Paradise JL, Rockette HE, et al. Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children. N Engl J Med. 2016 | Otitis Media |
Infectious Disease
|
Summary Link |
| Annane D, et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock”. The New England Journal of Medicine. 2018. 378(9):809-818. | Sepsis |
Critical Care
|
Summary Link |
| Comparison of patient-controlled epidural analgesia with patient-controlled intravenous analgesia using pethidine or fentanyl. | Pain |
Pain & Sedation
|
Summary Link |
| Comparison of intramuscular and epidural morphine for postoperative analgesia in the grossly obese. | Pain |
Pain & Sedation
|
Summary Link |
| GUSTO Trial, 1993 | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| GISSI-3 Group. “Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction”. The Lancet. 1994. 343(8906):1115-22. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Efficacy and safety of topical ciprofloxacin/dexamethasone versus neomycin/polymyxin B/ hydrocortisone for otitis externa | Otitis Externa |
Pediatrics
|
Summary Link |
| Early goal-directed therapy in the treatment of severe sepsis and septic shock | N/A |
Critical Care Medicine
|
Summary Link |
| Clinical Efficacy of Beta-1 Selective Beta-Blockers Versus Propranolol in Patients With Thyroid Storm: A Retrospective Cohort Study | N/A |
Endocrinology
|
Summary Link |
| Evaluating a novel pharmacist-led buprenorphine outreach service for treatment of opioid use disorder in individuals residing in supportive housing | N/A |
Addiction Medicine
|
Summary Link |
| Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty | N/A |
Cardiology
|
Summary Link |
| A pharmacist-driven deprescribing protocol for negative urine and sexually transmitted infection cultures in the emergency department increases antibiotic-free days | N/A |
Emergency Medicine
Infectious Diseases
|
Summary Link |
| Impact of a calcium replacement protocol during massive transfusion in trauma patients at a level 2 trauma center | N/A |
Trauma Surgery/Internal Medicine
|
Summary Link |
| Nebulized medications in the emergency department: A narrative review of nontraditional agents | N/A |
Emergency Medicine
|
Summary Link |
| Rivaroxaban in Patients with a Recent Acute Coronary Syndrome | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Rabies post-exposure prophylaxis in the emergency department | N/A |
Emergency Medicine
|
Summary Link |
| High-dose versus low-dose intravenous nitroglycerine for sympathetic crashing acute pulmonary edema: a randomised controlled trial | N/A |
Emergency Medicine
|
Summary Link |
| Ribociclib plus Endocrine Therapy in Early Breast Cancer | N/A |
Oncology
|
Summary Link |
| Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock | N/A |
Critical Care Medicine
|
Summary Link |
| Preparation/Administration of Push-Dose versus Continuous Infusion Epinephrine and Phenylephrine: A Simulation | N/A |
Emergency Medicine
|
Summary Link |
| Real world utilization of Andexanet alfa in the management of oral factor Xa inhibitor-associated gastrointestinal bleeding | Gastrointestinal Bleeding |
Hematology
|
Summary Link |
| Evaluating the impact of a discharge pharmacy in the emergency department on emergency department revisits and admissions | N/A |
Emergency Medicine
|
Summary Link |
| Tranexamic acid for angiotensin converting enzyme inhibitor induced angioedema: A retrospective multicenter study | N/A |
Emergency Medicine
|
Summary Link |
| Opioid Prescribing by Emergency Physicians: Trends Study of Medicare Part D Prescriber Data 2013-2019 | N/A |
Addiction Medicine
|
Summary Link |
| Prothrombin Complex Concentrate Administration Timing in Warfarin-Associated Intracranial Hemorrhage | N/A |
Hematology
|
Summary Link |
| Impact of emergency medicine clinical pharmacist practitioner-driven sepsis antibiotic interventions | N/A |
Pharmacy
|
Summary Link |
| Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis | N/A |
Gastroenterology
|
Summary Link |
| Operationalizing the new DEA exception: A novel process for dispensing of methadone for opioid use disorder at discharge from acute care settings | N/A |
Addiction Medicine
|
Summary Link |
| A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group | N/A |
Cardiology
|
Summary Link |
| Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction | N/A |
Cardiology
|
Summary Link |
| Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction | N/A |
Cardiology
|
Summary Link |
| PEGASUS-TIMI 54. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events | Secondary Prevention |
N/A
|
Summary Link |
| FRISC Investigators. “Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study”. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| CAPRICORN Trial Dargie HJ, et al. “Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial”. The Lancet. 2001. 357(9266):1385-1390. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| Cumulative epinephrine dose during cardiac arrest and neurologic outcome after extracorporeal cardiopulmonary resuscitation | Cardiac Arrest |
Resuscitation
|
Summary Link |
| Tenecteplase Compared with Alteplase for Acute Ischaemic Stroke in Canada (AcT) | N/A |
Emergency Medicine
Neurology
|
Summary Link |
| AURORA Study . Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis” | Secondary Prevention |
N/A
|
Summary Link |
| Full-dose challenge of moderate, severe, and unknown beta-lactam allergies in the emergency department | Beta Lactam Allergy |
Emergency Medicine
|
Summary Link |
| Bhatt DL, et al. “Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events”. The New England Journal of Medicine. 2013. 368(14):1303-1313. | Acute Coronary Syndrome |
Cardiology
|
Summary Link |
| CAST Trial. Mortality and morbidity in patients receiving Encainide, Flecainide, or Placebo | Ventricular Arrythima |
Cardiology
|
Summary Link |
| ECASS III | Acute Ischemic Stroke |
Neurology
|
Summary Link |
| A pharmacist-driven deprescribing protocol for negative urine and sexually transmitted infection cultures in the emergency department increases antibiotic-free days | Sexually Transmitted Disease, Urinary Tract Infection |
Emergency Medicine
|
Summary Link |
| ACURASYS | N/A |
Critical Care Medicine
|
Summary Link |
| TTM2: Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest | N/A |
Critical Care Medicine
|
Summary Link |
| BICAR-ICU | N/A |
Critical Care Medicine
|
Summary Link |