Pre-Quiz: Stress Ulcer Prophylaxis

Which of the following mechanisms can contribute to the development of stress ulcers in critically ill patients?

A) Increased catecholamine release leading to reduced mucosal blood flow
B) Impaired mucus and bicarbonate production
C) Elevated gastric pH weakening the mucosal barrier
D) Both A and B

A patient receiving scheduled pantoprazole for stress ulcer prophylaxis remains intubated in the ICU for 12 days. The ICU team should consider which of the following regarding the pantoprazole regimen?

A) Increase the dose to achieve better acid suppression
B) Change to an H2-receptor antagonist to reduce costs
C) Discontinue once the patient is extubated and tolerating oral intake
D) Continue indefinitely to prevent peptic ulcer disease

Which of the following adverse effects is more likely to occur with high-dose, long-term use of proton pump inhibitors compared to H2-receptor antagonists?

A) Mental status changes
B) Hypomagnesemia
C) Constipation
D) Headache

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